Publications by authors named "Giancarlo D'ippolito"
Studies from high endemic areas, mostly China, indicate that surface antigen positive (HBsAg) chronic hepatitis B virus (HBV) infection is associated with an increased risk of developing diffuse large B-cell lymphoma (DLBCL), whereas studies in low endemic areas have provided conflicting results. Past infection, serologically defined by negative HBsAg and positive anti-core antibody (HBsAgHBcAb), has also been suggested to increase the risk of B-cell non-Hodgkin's lymphoma (NHL) in high endemic areas. We retrospectively reviewed unselected clinical records of 253 patients with DLBCL (54% male, aged 60.
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- The study addresses the complexities of treating immunocompromised patients infected with SARS-CoV-2, focusing on the effectiveness and potential side effects of antiviral and monoclonal therapies.
- It presents a case series of five adult patients with inborn errors of immunity (IEI) who received various combination therapies at three Italian referral centers, including monoclonal antibodies, antivirals, and convalescent plasma.
- The findings suggest that combination therapy may be beneficial for complicated IEI patients who have weak antibody responses and struggle with vaccine efficacy.
Background: CVID patients present an increased risk of prolonged SARS-CoV-2 infection and re-infection and a higher COVID-19-related morbidity and mortality compared to the general population. Since 2021, different therapeutic and prophylactic strategies have been employed in vulnerable groups (vaccination, SARS-CoV-2 monoclonal antibodies and antivirals). The impact of treatments over the last 2 years has not been explored in international studies considering the emergence of viral variants and different management between countries.
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