Publications by authors named "Giancarlo Cascarano"
Objectives: To analyse the response to immunosuppressants (IS) in extrarenal flares of SLE to determine the most appropriate timing during follow-up for a change in therapeutic strategy.
Methods: Observational cohort study including a total of 81 patients with SLE with extrarenal flares requiring a change in IS over the period 2015-2022. Baseline clinical variables were described, and follow-up data at 1, 3, 6 and 12 months time-points were collected.
Article Synopsis
- * The analysis involved reviewing data from 422 patients, where 102 received BEL. Key findings included significant improvements in disease control, with 47% of patients achieving low disease activity after 6 months, increasing to 75% after 12 months.
- * The study concluded that BEL is effective for managing SLE and is increasingly being used earlier in treatment, which can lead to lower glucocorticoid (GC) dosages over time compared to later treatment strategies.
Article Synopsis
- SLE (Systemic Lupus Erythematosus) is primarily an autoimmune disease affecting women, but gender differences in its progression and treatment response are not fully understood.
- A study analyzed data from 417 SLE patients (51 men, 366 women) to investigate gender-related differences regarding disease onset, treatment, and long-term outcomes.
- Findings indicated men had a later disease onset and higher rates of specific conditions, while women experienced more hematological issues and used more azathioprine and glucocorticoids; however, overall disease outcomes were similar across genders, suggesting the need for close monitoring in both sexes.
Article Synopsis
- - Systemic lupus erythematosus (SLE) is a long-lasting autoimmune disorder that can cause various symptoms and occurs in cycles of flare-ups and remission.
- - Recent research has revealed new information on SLE's underlying causes, potential biomarkers for diagnosis, and innovative treatment approaches to better manage the disease.
- - The review focuses on significant findings from 2022 regarding SLE, including insights into associated health issues and the reproductive health of individuals affected by the disease.
Article Synopsis
- - The study aimed to analyze extra-renal flares in Systemic Lupus Erythematosus (SLE), categorize them based on initial characteristics, and create a machine learning model to predict 'difficult to treat' (D2T) flares.
- - Researchers examined 420 SLE patients over five years, finding that 79 extra-renal flares were prevalent, mainly affecting the skin and joints, with a notable proportion classified as D2T due to insufficient remission rates after treatment.
- - The findings revealed that certain flare clusters, particularly those involving skin issues, had lower remission rates and required higher doses of glucocorticoids, emphasizing the need for better management strategies and supporting the potential