Publications by Gian Tizio Rosalen

Publications by authors named "Gian Tizio Rosalen"

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DNA end sensing and cleavage by the Shedu anti-phage defense system.

Luuk Loeff Alexander Walter Gian Tizio Rosalen Martin Jinek

Cell

February 2025

The detection of molecular patterns associated with invading pathogens is a hallmark of innate immune systems. Prokaryotes deploy sophisticated host defense mechanisms in innate anti-phage immunity. Shedu is a single-component defense system comprising a putative nuclease SduA.

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