Publications by authors named "Gian Mario Nano"
Article Synopsis
- * The choice of oxidant significantly impacts reaction rates and yields, with both molecular oxygen and 3-bromo-4-hydroxycoumarin yielding excellent results.
- * Although the 3-arylation of 3-bromo-4-hydroxycoumarin did not succeed and led only to homocoupling products (symmetric biaryls), using HIU provides operational benefits and expands the Suzuki reaction's applications.
Squalene-hopene cyclase (SHC) is a useful model enzyme for predicting molecular interactions with oxidosqualene cyclase (OSC). Structure--activity relationships were investigated for numerous coumarin-derived inhibitors of SHC, and structural simplifications are suggested. Both umbelliferone and 2,4-dihydroxyacetophenone provide convenient starting nuclei for the design of SHC inhibitors.
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