Publications by authors named "Giacomo Setti"

: Potential adverse effects and pH-related effectiveness of bleaching agents have raised some concerns. The aim of this study was to compare three bleaching agents containing hydrogen peroxide (HP) and carbamide peroxide (CP) in terms of whitening effectiveness, pH variation, and changes in enamel surface roughness. : After controlled staining with a black tea solution, 42 human enamel specimens underwent bleaching treatment using the following agents: HP 40%; HP 35%; CP 16%.

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Article Synopsis
  • Mucous membrane pemphigoid (MMP) is an autoimmune disease that causes blistering mainly in mucous membranes, with rare cases affecting the skin; a case study highlighted the impact of the drug etanercept on MMP-like symptoms in a 40-year-old woman.* -
  • The symptoms, including recurring desquamative gingivitis, were linked to the timing of drug treatment, with flare-ups occurring when the drug was resumed and improvement when it was stopped, supported by laboratory findings.* -
  • The case identifies a possible adverse drug reaction and discusses the significance of TNF-α in the condition's mechanism, emphasizing the complexity of autoimmune disorders, medication interactions, and external influences like viral infections like
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Objectives: Optimal time to enucleation following marsupialization of large odontogenic mandibular cysts is undefined. We aim to assess volume reduction throughout follow-up, to indicate optimal time to enucleation. Secondary objectives include the identification of factors influencing cyst reduction.

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Primary Sjögren's Syndrome (pSS) is a multi-system autoimmune disease that involves the exocrine glands. Lymphocytes infiltrate the gland tissue, leading to anatomical modification and hypofunction. Even if the prognosis of pSS is favorable, quality of life is typically reduced due to the diverse manifestations of the disease.

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Despite novel treatment approaches, oral cancer survival has not improved significantly and the disease often presents a disabling path for patients. The aim of this work was to describe the epidemiological data of oral cancers in a province of northern Italy. Incident cases in the period 1996-2020 and EU population standardized rates were reported for Oral Cavity cancer (OC) and OroPharyngeal cancer (OP).

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Background: Acute myocardial infarction (AMI) accounts for about 7 million deaths per year worldwide. The early identification of signs and symptoms and the detection of specific serological markers of this disease are mandatory to reach a prompt diagnosis and begin potentially life-saving treatment. Point-of-care technologies applied to salivary diagnostics can provide rapid, simple, low-cost, and accurate measurements of specific markers and can also be used in emergency settings.

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Article Synopsis
  • This study investigates the metabolic composition of saliva to find non-invasive diagnostic biomarkers for oral health, focusing on submandibular/sublingual saliva, which has not been thoroughly analyzed before.
  • Researchers analyzed saliva samples from 20 healthy individuals using nuclear magnetic resonance and identified varying metabolites present in different saliva types: whole, parotid, and submandibular/sublingual.
  • The findings revealed specific metabolites unique to each saliva subtype and laid the groundwork for further research into salivary biomarkers related to oral and systemic health issues.
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Background: Systemic sclerosis is a connective tissue disease. Skin involvement of the mouth and hand may compromise function and quality of life. Autologous fat grafting has been described as a specific treatment of these clinical features.

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Unlabelled: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malignancies and systemic diseases is rapidly increasing. The present systematic review was developed for answering the question: "Are salivary microRNAs reliable biomarkers for diagnosis of cancer and systemic diseases?"

Methods: The application of inclusion and exclusion criteria led to the selection of 11 papers.

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Background: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer.

Case Presentation: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman.

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Malignant epithelioid hemangioendothelioma (MEH), or high-risk epithelioid hemangioendothelioma, is a low- to intermediate-grade vascular malignancy. A few cases of MEH have been documented in the head and neck region, including the neck, thyroid gland, larynx and scalp. MEHs are extremely rare in the oral cavity.

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