Publications by authors named "Giacomo Renno"
The objective of this study was to create artificial enzymes that capitalize on pnictogen bonding, a σ-hole interaction that is essentially absent in biocatalysis. For this purpose, stibine catalysts were equipped with a biotin derivative and combined with streptavidin mutants to identify an efficient transfer hydrogenation catalyst for the reduction of a fluorogenic quinoline substrate. Increased catalytic activity from wild-type streptavidin to the best mutants coincides with the depth of the σ hole on the Sb(V) center, and the emergence of saturation kinetic behavior.
View Article and Find Full Text PDFAnion-π catalysis, introduced in 2013, stands for the stabilization of anionic transition states on π-acidic aromatic surfaces. Anion-π catalysis on carbon allotropes is particularly attractive because high polarizability promises access to really strong anion-π interactions. With these expectations, anion-π catalysis on fullerenes has been introduced in 2017, followed by carbon nanotubes in 2019.
View Article and Find Full Text PDFArticle Synopsis
- Imidazo[1,5-]pyridine is a stable chemical scaffold that is effective for creating fluorescent compounds used in fields like optoelectronics and chemical biology, making them promising cell membrane probes.
- Five fluorophores based on this scaffold were synthesized using a one-pot method and tested for their ability to indicate membrane dynamics and cellular health.
- The study found that these probes showed excellent solvatochromic behavior and successfully intercalated into liposomes, suggesting their potential for future research as fluorescent agents in membrane studies.