Publications by authors named "Giacomo Marchini"
The human brain is the most complex organ in biology. This complexity is due to the number and the intricate connections of brain cells and has so far limited the development of in vitro models for basic and applied brain research. We decided to create a new, reliable, and cost-effective in vitro system based on the Nichoid, a 3D microscaffold microfabricated by two-photon laser polymerization technology.
View Article and Find Full Text PDFArticle Synopsis
- - JNKs, particularly JNK3, are stress-response protein kinases mainly found in the brain and other specific tissues, playing a crucial role in stress signaling and synaptic function related to neurodegeneration.
- - The JNK3 signaling pathway involves a series of carefully regulated phosphorylation steps, with specificity ensured by scaffold proteins like JIP1 and β-arrestin2.
- - Using techniques like super-resolution microscopy and co-immunoprecipitation, researchers demonstrated that JNK3 interacts with PSD95 and the scaffold proteins JIP1 and β-arrestin2 in neurons, suggesting these interactions could be targets to modulate synaptic events affected by stress.