Publications by authors named "Giacomo Ducci"
Glucagon-like peptide-1 receptor (GLP-1R) is a key regulator of glucose metabolism known to be expressed by pancreatic β cells. We herein investigated the role of GLP-1R on T lymphocytes during immune response. Our data showed that a subset of T lymphocytes expresses GLP-1R, which is upregulated during alloimmune response, similarly to PD-1.
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- Progranulin is a growth factor crucial for embryonic development and maintaining tissue health, but its deficiency is linked to serious brain disorders like frontotemporal dementia.
- While low levels are problematic in the brain, high levels of progranulin are found in various cancers, suggesting it could be useful for cancer diagnosis and prognosis.
- In cancer, progranulin promotes tumor growth and invasion by interacting with signaling pathways, particularly through the EphA2 receptor, but the detailed mechanisms of how it functions in different cancer types are still being researched.
Article Synopsis
- Three-dimensional cancer models, like spheroids, replicate tumor biology better than traditional 2D cultures, making them valuable for studying cancer metabolism.
- The Agilent Seahorse XFe96 system offers insights into cancer cell metabolism, but its use with 3D cultures hasn't been fully refined until now.
- An optimized workflow improves spheroid uniformity and allows for detailed metabolic analysis, revealing that metabolic variations are primarily due to the cancer cell line rather than spheroid size.
Bladder cancer is one of the most prevalent deadly diseases worldwide. Grade 2 tumors represent a good window of therapeutic intervention, whose optimization requires high resolution biomarker identification. Here we characterize energy metabolism and cellular properties associated with spreading and tumor progression of RT112 and 5637, two Grade 2 cancer cell lines derived from human bladder, representative of luminal-like and basal-like tumors, respectively.
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