[Autosomal dominant polycystic kidney disease : a pediatric perspective].

Polycystic kidney disease (PKD) is the most prevalent inherited kidney disease. The disease is usually asymptomatic until adulthood. End-stage renal disease occurs generally after the age of 55 years, with a large inter-individual variability.

[Type 1 primary hyperoxaluria: From childhood to adult, how to manage adequately medical therapy compliance?].

We report the cases of three young patients suffering from type 1 primary hyperoxaluria, a metabolic genetic disorder characterized by intracellular accumulation of oxalate and which may result in end-stage renal disease with systemic impairment. A number of effective conservative therapeutic means are available for early management of affected children particularly when he is growing older. Despite the demonstrated efficacy of conservative therapy, compliance represents a major and daily challenge.

Ultrasound Diagnosis and Follow-Up of Neonate Renal Candidiasis.

Urinary tract infection by Candida Albicans is a severe condition that can occur in infants during the course of a preterm or intensive care hospitalization. Candidiasis can affect the kidney and dramatically impair renal function through involvement of the renal cortex, typically associated with potentially obstructive pelvi-caliceal fungus balls. This case report describes the case of a 4.

Clinical characteristics and outcomes of children with stage 3-5 chronic kidney disease.

The aim of this study was to report on the clinical characteristics and outcomes of Belgian children with chronic kidney disease (CKD). Between 2001 and 2005, we followed 143 new successive patients younger than 20 years of age with a glomerular filtration rate of <60 ml/min/1.73 m(2) prospectively in a Belgian department of pediatric nephrology.

[Clinical case of the month. Nutcracker syndrome in association with a painful nephrologic disease].

Compression of the left renal vein between the aorta and the superior mesenteric artery causes a physiological condition, the so-called nutcracker phenomenon, but it can sometimes lead to left venous hypertension, or "nutcracker syndrome". Classical manifestations of which are an association of left flank pain, unilateral proteinuria and unilateral hematuria, without renal impairment. We report an atypical association of nutcracker syndrome with IgM nephropathy.

[Retrocaval ureter in a 10-year-old boy].

Retrocaval ureter is an uncommon abnormality of the inferior vena cava, which is rarely detected in the child due to its non-specific symptomatology. Despite a varying state of severity, chronic ureteral obstruction generally leads to the deterioration of renal function during adulthood. Treatment depends on the symptomatology in question, and surgical management should be as conservative as possible.

Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview.

The interactions between three class A beta-lactamases and three beta-lactamase inactivators (clavulanic acid, sulbactam and olivanic acid MM13902) were studied. Interestingly, the interaction between the Streptomyces cacaoi beta-lactamase and clavulanate indicated little irreversible inactivation. With sulbactam, irreversible inactivation was found to occur with the three studied enzymes, but no evidence for transiently inactivated adducts was found.