Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism.

Background: Thrombophilia is a substantial source of indisposition and mortality in several countries, including Arab populations. Deep venous thrombosis (DVT) with or without pulmonary embolism (PE) is the prevalent clinical manifestation of thrombophilia. While many genetic risk factors for DVT are known, almost all associated with hemostasis, many genetic factors remain unexplained.

Eugenol attenuates TiO nanoparticles-induced oxidative damage, biochemical toxicity and DNA damage in Wistar rats: an in vivo study.

Titanium dioxide nanoparticles (TiO NPs) are widely used in food, edible dyes, and other commercial products. Human exposure to TiO NPs has raised concerns regarding their toxic potential. Various studies have evaluated the TiO NPs-induced toxicity, oxidative damage to the cellular components, and genotoxicity.

The dual clastogenic and anti-clastogenic properties of quercetin is dose dependent.

Iron is a ubiquitous constituent of cytochromes, oxygen-binding molecules and a variety of enzymes because of its property to transition from ferric (Fe) to ferrous (Fe) state, leading to change in the redox potential. However, the same property accounts for free radical injury. In order to overcome harmful effects of iron we investigated the possible protective effect of quercetin (QCT), a flavonoid with antioxidant property, against the oxidative DNA damage caused by iron sulfate .