Publications by authors named "Ghulam Mohiuddin"

Coal mining industry is one of the main source for economy of every nations, whereas safety in the underground coal mining area is still doubtful. According to some reports, there is heavy loss of life and money due to the occasional accidents in the coal mining area. Some existing researchers has been addressed this issue and approached their method.

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Unlabelled: Esophageal leiomyomas (EL) are the most common benign tumors of the esophagus, being pedunculated polyp presentation is very rare. A 65-year-old female presented with symptoms of troublesome dysphagia. Esophagogastroduodenoscopy (EGD) performed revealed a pedunculated polyp of ~ 3 × 1.

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Background: Peptic ulcer disease (PUD) remains a significant healthcare burden, contributing to morbidity and mortality worldwide. Despite advancements in therapies, its prevalence persists, particularly in regions with widespread nonsteroidal anti-inflammatory drugs (NSAIDs) use and infection.

Aim: To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal (GI) bleeding in Pakistani population.

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Current study is based on the biology-oriented drug synthesis (BIODS) of S-naproxen (NSAID) derivatives and the evaluation of their urease inhibitory potential. In this regard, a variety of S-naproxen derivatives 2-39 including hydrazide 1, Schiff bases 2-21, aroyl substituted hydrazides 22-24, sulfohydrazides 25-34, 2-mercapto oxadiazole 35, phenacyl substituted 2-mercapto oxadiazoles 36-39 were synthesized under the umbrella of BIODS by simple chemical transformation of its pharmacophoric carboxylic group. Compounds 1-39 were evaluated for in vitro urease inhibitory activity and most of them showed good to moderate inhibitory potential in the range of IC = 14.

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