Tunneled Dialysis Catheter Insertion in External Jugular Vein by Nephrologists.

Background: External jugular vein (EJV) is used to insert tunneled dialysis catheter (TDC) in patients with no AVF and exhausted right internal jugular veins (IJV). There is scarce data on TDC insertion in EJV by nephrologists with fluoroscopy guidance.

Materials And Methods: This was a prospective observational study that included hemodialysis patients with exhausted right IJV access who underwent EJV TDC insertion, and excluded occluded ipsilateral brachiocephalic vein or superior vena cava, EJV < 5 mm diameter, or patients with existing EJV TDC.

Renal limited sarcoidosis presenting with acute kidney injury.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology, characterized by noncaseating epithelioid granuloma, multinucleate giant cells, and tissue destruction. While lung and lymph node involvement is common, isolated renal involvement is rare. We report the case of a 55-year-old female patient, with renal limited sarcoidosis, who presented with worsening sensorium and acute kidney injury.

All-Metal Metamaterial-Based Sensor with Novel Geometry and Enhanced Sensing Capability at Terahertz Frequency.

This research proposes an all-metal metamaterial-based absorber with a novel geometry capable of refractive index sensing in the terahertz (THz) range. The structure consists of four concentric diamond-shaped gold resonators on the top of a gold metal plate; the resonators increase in height by 2 µm moving from the outer to the inner resonators, making the design distinctive. This novel configuration has played a very significant role in achieving multiple ultra-narrow resonant absorption peaks that produce very high sensitivity when employed as a refractive index sensor.

A Potent Bis-Heteroleptic Ruthenium(II) Complex-Based Chalcogen Bonding Receptor for Selective Sensing of Phosphates.

The incorporation of a selenoimidazolium-based chalcogen bond (ChB) donor into a bis-heteroleptic Ru(II) complex (Ru-Se) has been designed for the first time to explore its anion-sensing properties and understand its selectivity to specific classes of anions. Photophysical studies demonstrate the receptor's selectivity toward phosphates, while H NMR displays its ability to recognize both I and HPO among the different halides and oxoanions through ChB interaction in CHCN and dimethyl sulfoxide- solvents, respectively. Additionally, microscopic studies such as DLS and TEM reveal that the selective turn-on sensing of HPO and HPO compared to I is driven by supramolecular aggregation behavior.

Cross-Coupling Reactions with Nickel, Visible Light, and -Butylamine as a Bifunctional Additive.

Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand design and base selection, achieving effective synergy between these components remains challenging. We present here a general approach to nickel-catalyzed photoredox reactions employing -butylamine as a cost-effective bifunctional additive, acting as the base and ligand.

Exploring the anti-diabetic potential of : isolation and characterization of bioactive compounds.

We investigated the anti-diabetic effects of the ethyl acetate fraction of and its isolated compounds using both and study models. tests showed that the ethyl acetate part of and its separate compounds had better activity blocking α-glucosidase, α-amylase, and α-lipase. The ethyl acetate fraction and its active constituents, barbaloin and gallic acid, significantly ( < 0.

Author Response: Insights into Immunomodulatory Therapy for Sepsis.

Ghosh I, Sangha SS, Pandey G, Srivastava A. Author Response: Insights into Immunomodulatory Therapy for Sepsis. Indian J Crit Care Med 2025;29(1):91.

Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling.

Background: Hybrid closed-loop systems are a new class of technology to manage type 1 diabetes mellitus. The system includes a combination of real-time continuous glucose monitoring from a continuous glucose monitoring device and a control algorithm to direct insulin delivery through an insulin pump. Evidence suggests that such technologies have the potential to improve the lives of people with type 1 diabetes mellitus and their families.

Vibronic Conical Intersection Trajectory Signatures in Wave Packet Coherences.

Conical intersections are ubiquitous in the energy landscape of chemical systems, drive photochemical reactivity, and are extremely challenging to observe spectroscopically. Using two-dimensional electronic spectroscopy, we observe the nonadiabatic dynamics in Wurster's Blue after excitation to the lowest two vibronic excited states. The excited populations relax ballistically through a conical intersection in 55 fs to the electronic ground state potential energy surface as the molecule undergoes an intramolecular electron transfer.

Health Care Professionals' Experience of Using AI: Systematic Review With Narrative Synthesis.

Background: There has been a substantial increase in the development of artificial intelligence (AI) tools for clinical decision support. Historically, these were mostly knowledge-based systems, but recent advances include non-knowledge-based systems using some form of machine learning. The ability of health care professionals to trust technology and understand how it benefits patients or improves care delivery is known to be important for their adoption of that technology.

Correlating tissue and plasma‑specific piRNA changes to predict their possible role in pancreatic malignancy and chronic inflammation.

The aggressiveness of pancreatic ductal adenocarcinoma is primarily due to lack of effective early detection biomarkers. Circulating non-coding RNAs serve as diagnostic or prognostic biomarkers in multiple types of cancer. Comparison of their expression between diseased tissue and relevant body fluids such as saliva, urine, bile, pancreatic juice, blood etc.

Efficacy of Polymyxin B Hemoperfusion for Treatment of Sepsis.

Objectives: To study the efficacy of polymyxin B hemoperfusion in addition to standard care for sepsis treatment.

Materials And Methods: Fifty sepsis patients (mean age 54.26 ± 14.

Predicting pedestrian-vehicle interaction severity at unsignalized intersections.

Objectives: This study aims to develop and validate a novel deep-learning model that predicts the severity of pedestrian-vehicle interactions at unsignalized intersections, distinctively integrating Transformer-based models with Multilayer Perceptrons (MLP). This approach leverages advanced feature analysis capabilities, offering a more direct and interpretable method than traditional models.

Methods: High-resolution optical cameras recorded detailed pedestrian and vehicle movements at study sites, with data processed to extract trajectories and convert them into real-world coordinates precise georeferencing.

Optically accessible long-lived electronic biexcitons at room temperature in strongly coupled H- aggregates.

Photon absorption is the first process in light harvesting. Upon absorption, the photon redistributes electrons in the materials to create a Coulombically bound electron-hole pair called an exciton. The exciton subsequently separates into free charges to conclude light harvesting.

Artificial intelligence software for analysing chest X-ray images to identify suspected lung cancer: an evidence synthesis early value assessment.

Background: Lung cancer is one of the most common types of cancer in the United Kingdom. It is often diagnosed late. The 5-year survival rate for lung cancer is below 10%.

Naringenin Against Cadmium Toxicity in Fibroblast Cells: An Integrated Network Pharmacology and In Vitro Metabolomics Approach.

Cadmium, a heavy metal, disrupts cellular homeostasis and is highly toxic, with no effective treatments currently available against its toxicity. According to studies, phytochemicals provide a promising strategy for mitigating cadmium toxicity. Naringenin (NG), a potent antioxidant found primarily in citrus fruits, showed protective properties against cadmium toxicity in rats.

On the higher-order smallest ring-star network of Chialvo neurons under diffusive couplings.

Network dynamical systems with higher-order interactions are a current trending topic, pervasive in many applied fields. However, our focus in this work is neurodynamics. We numerically study the dynamics of the smallest higher-order network of neurons arranged in a ring-star topology.

Chalcogen Bonding in Selective Recognition and Liquid-Liquid Extraction of Perrhenate.

Efficient recognition and extraction of hazardous anionic pollutants from water medium is of great significance for environmental concerns, representing a challenging area of research in supramolecular chemistry. In this study, we present, for the first time, a comprehensive demonstration of the ability of chalcogen bonding (ChB) to recognize and remove the ReO from 100 % water medium. The anion recognition ability is well elucidated through solution phase NMR and ITC studies, which clearly reveal the selective binding of ReO over other oxo-anions.

Improving healthcare professionals' interactions with patients to tackle antimicrobial resistance: a systematic review of interventions, barriers, and facilitators.

Introduction: Antimicrobial resistance (AMR) is a major public health threat. With the growing emphasis on patient-centred care/ shared decision making, it is important for healthcare professionals' (HCPs) who prescribe, dispense, administer and/or monitor antimicrobials to be adequately equipped to facilitate appropriate antimicrobial use. We systematically identified existing interventions which aim to improve HCPs interaction with patients and examined barriers and facilitators of appropriate the use of such interventions and appropriate antimicrobial use among both HCPs and patientsantimicrobial use while using these interventions.

: a novel hybrid quasi-fuzzy artificial neural network (ANN) model for estimation of reference evapotranspiration.

Reference evapotranspiration ( ) is a significant parameter for efficient irrigation scheduling and groundwater conservation. Different machine learning models have been designed for estimation for specific combinations of available meteorological parameters. However, no single model has been suggested so far that can handle diverse combinations of available meteorological parameters for the estimation of .

Supramolecular chemistry of liquid-liquid extraction.

Liquid-Liquid Extraction (LLE) is a venerable and widely used method for the separation of a targeted solute between two immiscible liquids. In recent years, this method has gained popularity in the supramolecular chemistry community due to the development of various types of synthetic receptors that effectively and selectively bind specific guests in an aqueous medium through different supramolecular interactions. This has eventually led to the development of state-of-the-art extraction technologies for the removal and purification of anions, cations, ion pairs, and small molecules from one liquid phase to another liquid phase, which is an industrially viable method.

HIV/HBV coinfection remodels the immune landscape and natural killer cell ADCC functional responses.

Background And Aims: HBV and HIV coinfection is a common occurrence globally, with significant morbidity and mortality. Both viruses lead to immune dysregulation including changes in natural killer (NK) cells, a key component of antiviral defense and a promising target for HBV cure strategies. Here we used high-throughput single-cell analysis to explore the immune cell landscape in people with HBV mono-infection and HIV/HBV coinfection, on antiviral therapy, with emphasis on identifying the distinctive characteristics of NK cell subsets that can be therapeutically harnessed.

Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity.

Long noncoding RNAs (lncRNAs) play crucial roles in maintaining cell homeostasis and function. However, it remains largely unknown whether and how neuronal activity impacts the transcriptional regulation of lncRNAs, or if this leads to synapse-related changes and contributes to the formation of long-term memories. Here, we report the identification of a lncRNA, SLAMR, which becomes enriched in CA1-hippocampal neurons upon contextual fear conditioning but not in CA3 neurons.