Mechanistic insights of free radical scavenging-driven stabilization of edible oils and their shelf life extension using CeO nanoparticles.

The rapid production of reactive oxygen species (ROS) due to lipid peroxidation of unsaturated bonds in wholesome vegetable oil during its storage and utilization happens to be the most alarming cause of concern in the edible oil industry. In researching for an ideal candidate to be used as an antioxidant, it has been identified that engineered CeO nanoparticle with curated surface chemistry (Ce3+/Ce4+ ratio) displays an enhanced ROS scavenging activity. Herein the CeO nanoparticles (∼100-110 nm) were manufactured though controlled synthesis protocol to achieve the desired outcome.

Development of a Paper-Based Disposal Thin-Film Solid-Phase Microextraction Tool for the Quantification of Environmentally Hazardous 4-Chlorophenol in Water.

The presence of chlorinated compounds in water resources presents various environmental and health risks. Therefore, there is a precise need to develop a potential technique for fast and efficient monitoring of chlorinated contaminants in water due to environmental protection and regulation compliance. Here, we designed a paper-based thin-film solid-phase microextraction (TF-SPME) patch to estimate 4-chlorophenol (4-CRP), a widely known environmentally hazardous pollutant in water samples.

Meeting report ASOBIOTICS 2024: an interdisciplinary symposium on antisense-based programmable RNA antibiotics.

The international symposium ASOBIOTICS 2024 brought together scientists across disciplines to discuss the challenges of advancing antibacterial antisense oligomers (ASOs) from basic research to clinical application. Hosted by the Helmholtz Institute for RNA-based Infection Research (HIRI) in Wurzburg, Germany, on September 12-13th, 2024, the event featured presentations covering major milestones and current challenges of this antimicrobial technology and its applications against pathogens, commensals, and bacterial viruses. General design principles and modification of ASOs based on peptide nucleic acid (PNA) or phosphorodiamidate-morpholino-oligomer (PMO) chemistry, promising cellular RNA targets, new delivery technologies, as well as putative resistance mechanisms were discussed.

Bioremediation by Brevibacterium sediminis: a prospective pyrene degrading agent to eliminate environmental polycyclic aromatic hydrocarbons.

Environmental abuses and subsequent array of health hazards by petroleum products have emerged as a global concern that warrants proper remediation. Pyrene (PYR), a polycyclic aromatic hydrocarbon, is a xenobiotic by-product during crude petroleum processing. Biodegradation potential of two bacterial isolates (MK4 and MK9) of Brevibacterium sediminis from oil contaminated sites was explored.

Wastewater-based surveillance of Vibrio cholerae: Molecular insights on biofilm regulatory diguanylate cyclases, virulence factors and antibiotic resistance patterns.

Vibrio cholerae is an inherent inhabitant of aquatic ecosystems. The Indian state of West Bengal, especially the Gangetic delta region is the highest cholera affected region and is considered as the hub of Asiatic cholera. V.

Clinical Significance of Faecal Calprotectin in Differentiating Inflammatory Bowel Disease from Irritable Bowel Syndrome.

Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder of the gastrointestinal tract with relapsing and remitting course. Recurrent abdominal pain and discomfort in association with abnormal defecation in the absence of structural abnormality of the gut is the key feature of irritable bowel syndrome (IBS). Faecal biomarker may be used a precise tool in the differentiation of IBD and IBS.

Determination of divalent metal ion-regulated proton concentration and polarity at the interface of anionic phospholipid membranes.

We studied the influence of trace quantities of divalent metal ions (M: Ca, Mg, and Zn) on proton concentration (-log[H], designated as pH') and polarity at the interface of anionic PG-phospholipid membranes comprising saturated and unsaturated acrylic chains. A spiro-rhodamine-6G-gallic acid (RGG) pH-probe was synthesized to monitor the interfacial pH' of large unilamellar vesicles (LUVs) at a physiologically appropriate bulk pH (6.0-7.

How to scan naked DNA using promiscuous recognition and no clamping: a model for pioneer transcription factors.

Most DNA scanning proteins uniquely recognize their cognate sequence motif and slide on DNA assisted by some sort of clamping interface. The pioneer transcription factors that control cell fate in eukaryotes must forgo both elements to gain access to DNA in naked and chromatin forms; thus, whether or how these factors scan naked DNA is unknown. Here, we use single-molecule techniques to investigate naked DNA scanning by the Engrailed homeodomain (enHD) as paradigm of highly promiscuous recognition and open DNA binding interface.

Recent advances in solid phase microextraction with various geometries in environmental analysis.

Solid phase microextraction (SPME) has emerged as a versatile sample preparation technique for the preconcentration of a broad range of compounds with various polarities, especially in environmental studies. SPME has demonstrated its eco-friendly credentials, significantly reducing the reliance on solvents. The use of biocompatible materials as a coating recipe facilitates the acceptance of SPME devices in analytical chemistry, primarily in the monitoring of environmental pollutants such as persistent organic pollutants (POPs), volatile organic compounds (VOCs), and pesticides from the various environmental matrices.

Psychometric Evaluation of the Bengali Short Form 12 Version 2 Health Survey in Patients With Inflammatory Bowel Disease.

Objectives: Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, significantly affects health-related quality of life (HRQOL). Despite the widespread use of the Short Form 12 version 2 (SF-12v2) questionnaire to assess HRQOL, its validity and reliability in Bengali IBD populations remain unclear. Our study aimed to evaluate the ability of the Bengali SF-12v2 to predict HRQOL in individuals with IBD.

Building and Maintaining a Whole Community Initiative: Health Communication in Practice with Be Well Communities™.

The most effective health communication builds from evidence-based best practices and theory. In practice, health campaigns rely on considerations often under-discussed in health communication, such as consistent agency-style client service, image management, and community coalition-building. Health outcome progress often requires change at multiple levels, from individual cognition and behavior to policy creation.

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high transverse momentum (high p_{T}) hadron trigger in proton-proton and central Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV. A data-driven statistical method is used to mitigate the large uncorrelated background in central Pb-Pb collisions.

Decoding the TAome and computational insights into parDE toxin-antitoxin systems in Pseudomonas aeruginosa.

Toxin-antitoxin (TA) modules are widely found in the genomes of pathogenic bacteria. They regulate vital cellular functions like transcription, translation, and DNA replication, and are therefore essential to the survival of bacteria under stress. With a focus on the type II parDE modules, this study thoroughly examines TAome in Pseudomonas aeruginosa, a bacterium well-known for its adaptability and antibiotic resistance.

Implementation and Evaluation of a Multi-level, Place-Based Tobacco Prevention and Control Program at a Minority-Serving Institution in Texas.

Multi-level, place-based interventions have proven effective at promoting a range of health behaviors, including tobacco control and discouraging the uptake of tobacco products. This paper describes the implementation and impact of a 3-year, multi-level tobacco prevention and control program at a community-college minority-serving institution (MSI) on the Texas Gulf Coast within the context of a broader multi-sector, cross-functional health coalition. The intervention studied included a tobacco-free policy, a large-scale communication campaign highlighting parts of the intervention and prevention and cessation resources.

Understanding the impact of community-based sun safety interventions on a college campus in Texas.

: Examine the impact of a community-based, multi-component sun intervention on the campus of Lee College in Baytown, Texas. : 735 respondents completed the survey as part of a range of campus topics. : Survey data on the program were gathered through an emailed campus-wide survey to better understand the community's perceptions and awareness as well as campaign effectiveness over time.

Impact of Ionic Liquids on the Physicochemical Behavior of Vesicles.

The effects of two ionic liquids (ILs), 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF) and 1-butyl-1-methyl pyrrolidinium tetrafluoroborate ([bmp]BF), on a mixture of phospholipids (PLs) 1,2-dipalmitoyl--glycero-3-phosphatidylcholine (DPPC), 1,2-dipalmitoyl--glycero-3-phosphoethanolamine (DPPE), and 1,2-dipalmitoyl--glycero-3-phosphoglycerol (DPPG) (6:3:1, M/M/M, 70% PL) in combination with 30 mol % cholesterol (CHOL) were investigated in the form of a solvent-spread monolayer and bilayer (vesicle). Surface pressure (π)-area () isotherm studies, using a Langmuir surface balance, revealed the formation of an expanded monolayer, while the cationic moiety of the IL molecules could electrostatically and hydrophobically bind to the PLs on the palisade layer. Turbidity, dynamic light scattering (size, ζ-potential, and polydispersity index), electron microscopy, small-angle X-ray/neutron scattering, fluorescence spectroscopy, and differential scanning calorimetric studies were carried out to evaluate the effects of IL on the structural organization of bilayer in the vesicles.

Physicochemical Studies on Amino Acid Based Metallosurfactants in Combination with Phospholipid.

Dicarboxylate metallosurfactants (AASM), synthesized by mixing N-dodecyl aminomalonate, -aspartate and -glutamate with CaCl, MnCl and CdCl, were characterized by XRD, FTIR, and NMR spectroscopy. Layered structures, formed by metallosurfactants, were evidenced from differential scanning calorimetry and thermogravimetric analyses. Solvent-spread monolayer of AASM in combination with soyphosphatidylcholine (SPC) and cholesterol (CHOL) were studied using Langmuir surface balance.

Conformational Switch of a Peptide Provides a Novel Strategy to Design Peptide Loaded Porous Organic Polymer for Pyroptosis Pathway Mediated Cancer Therapy.

While peptide-based drug development is extensively explored, this strategy has limitations due to rapid excretion from the body (or shorter half-life in the body) and vulnerability to protease-mediated degradation. To overcome these limitations, a novel strategy for the development of a peptide-based anticancer agent is introduced, utilizing the conformation switch property of a chameleon sequence stretch (PEP1) derived from a mycobacterium secretory protein, MPT63. The selected peptide is then loaded into a new porous organic polymer (PG-DFC-POP) synthesized using phloroglucinol and a cresol derivative via a condensation reaction to deliver the peptide selectively to cancer cells.