Breaking Barriers: Addressing Gender Disparities in Hip Resurfacing Surgery Access in the United States.

Second-generation large-diameter head hip resurfacing (HR) arthroplasty has gained popularity in terms of its potential for minimal wear and the preservation of proximal femoral bone stock. HR faces challenges, such as increased hip fracture rates and adverse reactions to metal detritus, despite the fact that over one million metal-on-metal (MoM) arthroplasties have been performed globally. FDA issued warnings in 2011 and 2016 regarding higher failure rates in women and categorized MoM implants as high-risk, influencing U.

Effects and Mechanisms of Silibinin on Influenza A/H1N1 Pathogenesis in a Mouse Model.

Silymarin is a polyphenolic flavonoid extracted from milk thistle. It has potent immunomodulatory effects and can inhibit the replication of influenza A virus (IAV). The present study aimed to determine the inflammatory and anti-inflammatory cytokine secretion patterns in mice before and after silibinin treatment.

Effect of acupressure on childbirth outcomes in nulliparous women: A randomized clinical trial.

Background: Non-pharmaceutical method is one of the conventional methods of reducing labor pain. Acupressure is suggested as an effective method for reducing labor pain with favorable effects on the outcome of childbirth. Different acupressure methods are suggested for this purpose; the most effective one has to be investigated.

Advanced 3Dimentional engineered microenvironment to improve of in vitro spermatogenesis: narrative review.

Induction of in vitro spermatogenesis may be helpful in the treatment of infertility in azoospermic individuals and those undergoing chemotherapy. Different cultivation systems have been implemented to achieve this aim. This review study aimed to investigate the application of three-dimensional culture in the induction of in vitro spermatogenesis.

Innovative capsulation and microencapsulation of plant hormones: a strategy to combat plant pathogens.

One of the prevailing trends in contemporary agriculture is the application of biological control. Nevertheless, several reports suggest that biocontrol bacteria exhibit poor survival rates in host plants. Consequently, the concept of shielding biological control agents by encapsulating them in outer coatings has gained popularity.

Exploring the potential of gemcitabine-metal-organic frameworks in combating pancreatic cancer under ketogenic conditions.

Background: Inadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organo-metallic framework under ketogenic conditions in inhibiting the growth of MIA-PaCa-2 cells.

Methods: Gemcitabine was encapsulated in Metal-organic frameworks (MOFs) and its morphology and size distribution were examined using transmission electron microscopy (TEM) and Dynamic light scattering (DLS) with further characterization including FTIR analysis.

New Pyranopyrazole-Based Indolin-2,3-dione Hybrid as Effective Inhibitors of Xanthine Oxidase: Synthesis, In Vitro, and Molecular Modelling Approaches.

In the current study, new pyranopyrazole analogues (9a-d and 10a-d) were synthesized through a one-pot condensation reaction of 2-arylacetohydrazide. The inhibitory abilities were investigated against the XO enzyme through experimental and molecular docking analyses. The synthesis studies were based on ultrasound-mediated condensation reactions of four-component systems containing 2-arylacetohydrazide, ethyl acetoacetate, indoline-2,3-dione, and ethyl 2-cyanoacetate/malononitrile in various solvents and catalysts to yield pyranopyrazole analogues (9a-d and 10a-d) in a short reaction time and remarkably favorable yields ranging from 79-92%.

Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene-Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies.

Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication. As existing treatments often come with limitations, there is an increasing focus on creating novel therapeutic agents that offer greater efficacy and fewer side effects to better address this widespread issue.

Immunotherapeutic potentials of carnosol against lipopolysaccharides-induced acute inflammatory reactions in White Swiss albino mice.

Septic shock involves severe systemic inflammatory reaction toward various invading species, such as microorganisms and microbial toxins. Such a response is complicated and characterized as being a dynamic and time-dependent phenomenon. During this response, a significant amount of pro-inflammatory cytokines may be produced, causing a rapid death rate in septic victims and occasionally leading to apoptosis of immune cells within the first hours of septic reaction.

How necessary it is to perform a ventilation scan in patients with a history of COVID-19 to rule out pulmonary thromboembolism?

Objectives: This study evaluated the necessity of a ventilation scan in patients suspected of PE with a history of COVID-19 infection.

Methods: This was a cross-sectional study of patients with PCR-confirmed COVID-19 and suspected PE at a tertiary care hospital in 2020. They underwent ventilation/perfusion (V/Q) scintigraphy using single-photon emission computed tomography/computed tomography (SPECT/CT) and CT scans with or without contrast.

Radical Ring-Opening Polymerization: Unlocking the Potential of Vinyl Polymers for Drug Delivery, Tissue Engineering, and More.

Synthetic vinyl polymers have long been recognized for their potential to be utilized in drug delivery, tissue engineering, and other biomedical applications. The synthetic control that chemists have over their structure and properties is unmatched, allowing vinyl polymer-based materials to be precisely engineered for a range of therapeutic applications. Yet, their lack of biodegradability compromises the biocompatibility of vinyl polymers and has held back their translation into clinically used treatments for disease thus far.

The Effects of Acidified Nitrite on Wound Healing in Streptozotocin-Induced Diabetic Mice.

Background: Diabetes mellitus (DM) is one of the most common metabolic diseases in the world. Studies have shown that nitric oxide (NO) promotes re-epithelialization and stimulates angiogenesis and neovascularization. This study aimed to investigate the effect of exogenous NO on diabetic wound healing.

Association of dietary insulin index (DII) and dietary insulin load (DIL) with circadian rhythm and quality of sleep among overweight and obese women: a cross-sectional study.

Background: Obesity is a global issue, with over 1.9 billion adults overweight. Disruption of circadian rhythms (CR) leads to obesity and metabolic disorders.

Is vitamin D deficiency a more frequent finding in hirsutism or not?

Evidence shows that vitamin D (Vit D) insufficiency is associated with some hormonal disorders. Hirsutism is a prevalent hormonal condition, which is usually associated with excess of androgenic hormones. Disturbance of Vit D level affects the regulation of these hormones and may be associated with hirsutism.

Immunoinformatics approach: Developing a multi-epitope vaccine with novel carriers targeting monkeypox virus.

Since May 2022, the global spread of monkeypox virus (MPXV) has presented a significant threat to public health. Despite this, there are limited preventive measures available. In this study, different computational tools were employed to design a multi-epitope vaccine targeting MPXV.

Platelet-Leukocyte Aggregate and Interleukin-6: An Emerging Perspective on a New Diagnostic and Therapeutic Clue for Acute Coronary Syndrome, A Case-Control Study.

Background And Aims: Acute coronary syndrome (ACS) is one of the most important cardiovascular diseases. The rupture of atherosclerotic plaques in coronary arteries is considered the underlying pathophysiology of ACS. The interaction between cytokines and leukocytes in the presence of platelets results in platelet-leukocyte aggregate (PLA).

Computational and experimental insights into pharmacological potential: Synthesis, in vitro evaluation, and molecular docking analysis of bioactive urea and thiourea derivatives.

This study delves into the synthesis, in vitro assessment, and molecular docking analysis of bioactive urea and thiourea derivatives, which have garnered significant attention in pharmaceutical chemistry due to their versatile chemical reactivity and potential therapeutic applications One pot synthetic approach was utilized to develop a diverse class of these compounds. Subsequent biological assessments, including antimicrobial assays, demonstrated their pharmacological potential by inhibiting pathogenic microorganisms. Molecular docking analysis offered computational insights into the interactions between these compounds and specific biomolecules, shedding light on their potential mechanisms of action.

The Impact of Cholecystectomy on Bile Reflux After One Anastomosis Gastric Bypass.

Background: Bile reflux (BR) is an issue after one anastomosis gastric bypass (OAGB). Cholecystectomy can increase BR in patients without a history of metabolic and bariatric surgery. We aimed to evaluate the effect of cholecystectomy on BR after OAGB.

Intracranial hypertension and papilledema secondary to an unruptured arteriovenous malformation: Review of the literature.

Arteriovenous malformations (AVMs) are abnormal connections of arteries and veins without intermediate capillary components. As such, AVMs can remain asymptomatic or have a variety of clinical presentations ranging from mild headaches to severe symptoms like seizures, hemorrhage, and subsequent coma. Papilledema and increased intracranial pressure without hydrocephalus or hemorrhage are rare forms of presentations of cerebral AVM.

Pretreatment factors associated with symptomatic stroke in Moyamoya disease patients: A multicenter study.

Objectives: Moyamoya disease (MMD) is a cerebrovascular disorder marked by the progressive steno-occlusion of the bilateral internal carotid arteries and the formation of abnormal collateral vessel networks at the base of the brain. Previous studies have attempted to identify risk factors predictive of postoperative complications to improve patient management. This study aims to identify pretreatment factors associated with post-bypass symptomatic strokes in MMD patients.

Anti-oxidant and anti-apoptotic effects of royal jelly against polystyrene microplastic-induced testicular injury in mice.

Objectives: In recent years, microplastics (MPs), which are novel environmental contaminants measuring 5 mm in diameter, have garnered considerable attention. However, information regarding substances that can mitigate the dangers of MPs for animals remains extremely limited.

Materials And Methods: Ninety days were devoted to the exposure of mature male mice to royal jelly (RJ) and 2 µm virgin polystyrene microplastics (PS-MPs) in this study.