The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility.

Cleft lip and cleft palate (CL/P) are among the most common congenital malformations in neonates and have syndromic or nonsyndromic forms. Nonsyndromic forms of malformation are being reported to be associated with chromosomal DNA modification by teratogenic exposure and to complex genetic contributions of multiple genes. Syndromic forms are shown to be related to chromosomal aberrations or monogenic diseases.

Meta-analysis of transcriptomic responses to cold stress in plants.

Transcriptomic analyses are needful tools to gain insight into the molecular mechanisms underlying plant responses to abiotic stresses. The aim of this study was to identify key genes differentially regulated in response to chilling stress in various plant species with different levels of tolerance to low temperatures. A meta-analysis was performed using the RNA-Seq data of published studies whose experimental conditions were comparable.

Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.

Background: Colorectal cancer (CRC) is one of the most common obesity-associated cancers. Inflammation is also considered the most important factor between obesity and CRC. This study aimed to examine miRNAs binding sites variants on inflammatory genes identified using bioinformatics and systematic approach on clinical samples that were collected from CRC patients and controls.

The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial.

Introduction: The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed the diffusion tensor imaging to assess the changes in the white matter structure.

Methods: Males and females aged 4 to 14 years old with spastic CP were included.

Molecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translation.

The c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can also mediate drug resistance and radioresistance in cancers.

Synthesis of new hybrid composite based on TiO for photo-catalytic degradation of sulfamethoxazole and pharmaceutical wastewater, optimization, performance, and reaction mechanism studies.

In this study photo-catalytic degradation of sulfamethoxazole (SMX) from aqueous solutions using carbon quantum dot (CQD)-decorated Cu-TiO was investigated. The as-prepared photo-catalyst samples were characterized by various FTIR, XRD, FE-SEM, TEM, EDX, BET, and DRS techniques. The investigation of effective photo-catalytic operational parameters confirmed that the complete removal of SMX (20 mg/L) can be accomplished at pH: 6.

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response.

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent in the treatment of this malignant disease. Macroautophagy/autophagy is a "self-degradation" mechanism capable of facilitating the turnover of long-lived and toxic macromolecules and organelles.

Role of genetic polymorphisms in recurrent aphthous stomatitis: A systematic review and meta-analysis.

Recurrent aphthous stomatitis (RAS) is one of the most common oral ulcerative diseases with unknown etiology. Identifying the genetic markers can improve medical care and prevention of RAS. Genetics variants inflammatory agents are associated with the risk of RAS.

The Role of 5-HT1A Receptors and Neuronal Nitric Oxide Synthase in a Seizur Induced Kindling Model in Rats.

Background And Objective: Dentate gyrus (DG) has a high density of 5-HT1A receptors. It has neural nitric oxide synthase (nNOS), which is involved in neural excitability. The purpose of this study was to investigate the role of 5-HT1A receptors and nNOS of DG in perforant path kindling model of epilepsy.

Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease.

Tryptophan (Trp), an α-amino acid, is the precursor of serotonin (5-hydroxytryptamine, 5-HT), which is involved in a variety of features of metabolic function and human nutrition. Evidence highlights the role of Trp metabolites (exclusively 5-HT) in the gastrointestinal (GI) tract; however, the mechanisms of action involved in the release of 5-HT in the GI tract are still unknown. Considering the fact that variations of 5-HT may facilitate the growth of certain GI disorders, gaining a better understanding of the function and release of 5-HT in the GI tract would be beneficial.

Risk assessment of heavy metals consumption through onion on human health in Iran.

Considering the importance of onions consumption in the household diet, controlling of heavy elements' concentration in foodstuffs is important to ensure the safety of an individual's health. This study aimed to evaluate the risk of heavy metals through onion consumption on human health. In this cross-sectional experimental study, 22 onion samples with varieties red, yellow, and white in the two autumn and winter seasons in 2020 were randomly collected from the different provinces of Kurdistan, Hamedan, and Kermanshah.

The effect of patient-centered education in adherence to the treatment regimen in patients with coronary artery disease.

This study aimed to determine the effect of patient-centered education on adherence to the treatment regimen in patients with coronary artery disease. It was a parallel randomized controlled study with a 1:1 allocation ratio. 104 patients who met the inclusion criteria were chosen through non-probability consecutive sampling and divided into intervention and control groups.

Oral health and dental caries experience among students aged 7-15 years old with autism spectrum disorders in Tehran, Iran.

Background: Autism spectrum disorders (ASD) are a set of developmental, psychological, and neurological disorders that occur in early childhood. The most important characteristic of individuals with autism is difficulty in social interactions and communication. Researchers in the field of oral health have not paid enough attention to these individuals due to their specific behavioral characteristics.

The long and short non-coding RNAs modulating EZH2 signaling in cancer.

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate in developmental and biological processes and their abnormal expression affects cancer progression. These RNA molecules can function as upstream mediators of different signaling pathways and enhancer of zeste homolog 2 (EZH2) is among them.

Determining the frequency of Candida species in women with candidal vaginal infection frequency of Candida species in women with candida vaginal infection.

Background: Candidiasis vaginitis is an opportunistic and common mucosal infection. Although is the most common isolated species, other species of Candida such as , and have also increased significantly in recent years. The aim of this study was to identify species in women with candidal vaginal infection in order to promote health in women.

OXA-CuS@UiO-66-NH as a drug delivery system for Oxaliplatin to colorectal cancer cells.

In this work, UiO-66-NH was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH.

Extraction and determination of organic/inorganic pollutants in the ambient air of two cities located in metropolis of Tehran.

In the present study, PM, volatile organic compounds (VOC), heavy metals, and polycyclic aromatic hydrocarbons (PAHs)-bonded PM as well as asbestos fibers were investigated in two cities in the east of Tehran, Iran. To this end, 72 samples were collected from six stations located in the cities of Varamin and Pakdasht from March 2018 to March 2019. The concentration of BTEX compounds, PAHs, and heavy metals were measured using gas chromatography-flame ionization detector (GC-FID), gas chromatography-mass spectrometry (GC-Mas), and inductively coupled plasma atomic emission spectroscopy (ICP-OES), respectively.

Near-harvest application of methyl jasmonate affected phenolic content and antioxidant properties in "Thompson Seedless" grape.

The influence of methyl jasmonate (MJ) preharvest treatment was investigated on some polyphenols and antioxidant systems in the "Thompson Seedless" table grape. The clusters were sprayed in the vineyard 2 days before harvest with 0, 1, 5, and 10 mM MJ. After picking, berries were stored for 6 days at 15°C, simulating marketing conditions.

Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance.

Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting its cytotoxicity in cancer.

Areas Covered: The favorable characteristics of GO nanocomposites, preparation method, and application in cancer therapy are described.

Combined training improves the diagnostic measures of sarcopenia and decreases the inflammation in HIV-infected individuals.

Background: HIV-related sarcopenia is an emerging health issue that often remains undiagnosed and can lead to reduced quality of life, independence, and premature death if untreated. This study investigated the effects of a 6 month combined training (resistance plus aerobic exercise) (CT) intervention on diagnostic measures of sarcopenia, including grip strength, appendicular lean mass index (ALMI), and gait speed.

Methods: Forty participants were randomized into either a CT group (n = 20; age = 38.

The effect of IGF-1 plasma concentration on COVID-19 severity.

Background: The severity and fatality of Coronavirus disease 2019 (COVID-19) infection are not the same in the infected population. The host immune response and Immune-stimulating factors appear to play a role in COVID-19 infection outcome. insulin-like growth factor-1 (IGF-1) affects the immune system by controlling the endocrine system.

Novel insertion mutation in the PLA2G6 gene in an Iranian family with infantile neuroaxonal dystrophy.

Background: Infantile neuroaxonal dystrophy is an autosomal recessive neurological disorder. Individuals with infantile neuroaxonal dystrophy experience progressive loss of vision, mental skills and muscular control, and other variable clinical signs. Pathogenic variants in the PLA2G6 gene, encoding phospholipase A2, are recognized to be the fundamental reason for infantile neuroaxonal dystrophy.

The effect of Ccnb1ip1 insulator on monoclonal antibody expression in Chinese hamster ovary cells.

Background: The increasing need for therapeutic monoclonal antibodies (mAbs) entails the development of innovative and improved expression strategies. Chromatin insulators have been utilized for the enhancement of the heterologous proteins in mammalian cells.

Methods And Results: In the current study the Ccnb1ip1 gene insulator element was utilized to construct a novel vector system for the expression of an anti-CD52 mAb in Chinese hamster ovary (CHO) cells.

Effect of spiritual care education on the spiritual health of preeclamptic women with postpartum stress disorder.

Background: Spiritual health in the field of health has a great importance in mental disorders and posttraumatic stress disorders, in treatment process. The present study was done aiming "determine the effect of spiritual care education on the spiritual health of preeclamptic women with postpartum stress disorder."

Materials And Methods: This randomized clinical trial was done in 2017 on 260 women with preeclampsia in Mashhad.

Investigating the relationship between the dimensions of mindfulness and maternal attachment to the fetus during pregnancy.

Background: Maternal attachment to the fetus is a term used to describe the emotional relationship between mother and fetus. This emotional connection increases during pregnancy and is reflected in her feelings, perceptions, and behaviors. Mindfulness is important as one of the factors affecting the mental health of people during pregnancy.