Evaluation of the therapeutic effect of a novel bacteriophage in the healing process of infected wounds with Klebsiella pneumoniae in mice.

Objective: Bacterial wound infections have recently become a threat to public health. The emergence of multidrug-resistant (MDR) strains of Klebsiella pneumoniae highlights the need for a new treatment method. The effectiveness of bacteriophages has been observed for several infections in animal models and human trials.

Isolation, Characterization and Evaluation of Specific Bacteriophages Targeting Extensive Drug Resistance Strains of Isolated from Septic Burn Wounds.

Background: Antibiotic resistant bacteria and various infections caused by them especially extensive drug resistance (XDR) strains and worrying statistics of mortality due to these strains and also the lack of a clear vision for development and production of new effective antibiotics have made the necessity of using alternative therapies more apparent.

Materials And Methods: In this study, specific phages affecting the XDR strain were extracted from hospital wastewater and their laboratory characteristics along with lysis effect on 40 XDR strains of were investigated.

Results: The results indicated that three isolated phages (PaB1, PaBa2 and PaBa3) belonged to the and families and were specific to strains.