Fabrication of uniform Pd nanoparticles immobilized on crosslinked ionic chitosan support as a super-active catalyst toward regioselective synthesis of pyrazole-fused heterocycles.

Selection of biodegradable chitosan as a raw material is a smart technique due to its easy modifiability and high renewability. Herein, taking advantage of these functional characteristics, an ionic biopolymer support is produced from copolymerization of allylated chitosan (with 48 % degree of substitution) and polymerizable ionic liquid ([MEVIm]Br). Next, palladium nanoparticles are successfully stabilized in this designed support through a facile manner based on interconnected porous network, ionic nature and rich functional groups.

A caffeine pre-treatment and sole effect of bone-marrow mesenchymal stem cells-derived conditioned media on hyperglycemia-suppressed fertilization.

As a common metabolic disorder, hyperglycemia (HG) affects and disrupts the physiology of various systems in the body. Transplantation of mesenchymal stem cells (MSCs) has been used to control the complications of disease. Most of the therapeutic properties of MSCs are attributed to their secretome.

A consecutive synthesis of spiro[cyclopenta[b]pyrrole-5,2'-indene] derivatives via spirocyclization/annulation reactions.

The reaction between ninhydrin-malononitrile adduct [2-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)malononitrile] and ethyl 2-(alkylamino)-4-aryl-4-oxo-but-2-enoates (prepared from ethyl 2,4-dioxo-4-arylbutanoate and alkylamines) in the presence of EtN in MeCN at room temperature afforded 3-alkylamino-2-aryloyl-1',3',4-trioxo-1',3'-dihydrospiro[cyclopentane-1,2'-inden]-2-ene-5,5-dicarbonitriles in 78-95% yields. Five derivatives of these NH-acidic compounds are used to intercept the reactive zwitterionic intermediates generated from dimethyl acetylenedicarboxylate and PhP to produce dimethyl 4,4-dicyano-6-aryloyl-1-alkyl-1',3'-dioxo-1',2,3',4-tetrahydro-1H-spiro[cyclopenta[b]pyrrole-5,2'-indene]-2,3-dicarboxylates. Radical scavenging activity of four derivatives was investigated by radical trapping of diphenylpicrylhydrazine and ferric reduction power experiments.

Ultrasound-Engineered fabrication of immobilized molybdenum complex on Cross-Linked poly (Ionic Liquid) as a new acidic catalyst for the regioselective synthesis of pharmaceutical polysubstituted spiro compounds.

A novel supported molybdenum complex on cross-linked poly (1-Aminopropyl-3-vinylimidazolium bromide) entrapped cobalt oxide nanoparticles has been successfully fabricated through two different procedures, i.e. ultrasound (US) irradiations (100 W, 40 kHz) and reflux.

The influence of the polymerization approach on the catalytic performance of novel porous poly (ionic liquid)s for green synthesis of pharmaceutical spiro-4-thiazolidinones.

Although poly (ionic liquids) (PILs) have attracted great research interest owing to their various applications, the performance of nanoporous PILs has been rarely developed in the catalysis field. To this end, a micro-mesoporous PIL with acid-base bifunctional active sites was designed and fabricated by two different polymerization protocols including hydrothermal and classical precipitation polymerization in this paper. Based on our observations, hydrothermal conditions (high temperature and pressure) enabled the proposed sonocatalyst to possess a great porous structure with a high specific surface area ( : 315 m g) and thermal stability (around 450 °C for 45% weight loss) through strengthening cross-linking.

Protective effect of leptin on induced apoptosis with trichostatin A on buffalo oocytes.

Leptin, the 16-kDa product of the obese (ob) gene, primarily secreted from adipose tissue, has been implicated to play an important role in the regulation of food intake and energy expenditure. This study investigated protective effect of leptin on trichostatin A-induced apoptotic on in vitro maturation ratio of buffalo oocytes. Ovaries were collected from abattoir and were transported immediately to the laboratory by a thermos flask containing sterile normal saline with antibiotics.

Synthesis, structure and characterization of a helical seven-coordinated pyridine-2,6-dicarboxylate-bridged cadmium(II) complex.

[Cd(C7H3NO4)(H2O)1.5]n or [Cd(2,6-pydc)(H2O)1.5]n, (1) (2,6-pydc = pyridine-2,6-dicarboxylate) was obtained from the reaction of pyridine-2,6-dicarboxylic acid and 4-hydroxypyridine-2,6-dicarboxylic acid with cadmium(II) nitrate tetrahydrate in the presence of piperazine and characterized by elemental analysis, IR spectra and X-ray single crystal diffraction.