Publications by authors named "Gholam Hossein Farjah"
Objectives: Unclassified gingival papules might be mistaken with other malignant lesions as they resemble some other oral lesions. The present study demonstrates epidemiologic and histopathological characteristics of the gingival unclassified papules in the patients referred to Urmia Dental School, Iran.
Materials And Methods: A cross sectional descriptive study design was conducted among 500 pateints in Urmai university of medical sciences, Iran.
Article Synopsis
- The article DOI: 10.1016/j.heliyon.2022.e10798 has some inaccuracies that need to be addressed.
- This correction aims to clarify and rectify those errors to enhance understanding.
- It emphasizes the importance of maintaining accuracy in academic publications for the benefit of researchers and readers alike.*
Background: Oxidative stress is a major contributor to diabetes mellitus (DM), which leads to testicular damage and infertility.
Objective: The aim of this study was to investigate the effects of glibenclamide (GL) as a chemical medicine and troxerutin (TR) as an herbal agent on sperm parameters and histopathological changes of testis in diabetic male rats.
Materials And Methods: Forty male Wistar rats (230-260 gr) were randomly divided into 5 groups (n = 8/each), including control, diabetic (D), GL, TR, and GL+TR.
Article Synopsis
- - The study explored how chlorogenic acid (CGA) can protect mouse testicular tissue from damage caused by ionizing radiation (IR) during pelvic cancer treatment.
- - Seventy mice were used in an experiment where one group was exposed to IR alone, while others were treated with various doses of CGA after IR exposure, and their testes were analyzed later.
- - Results showed that CGA, especially at 40 mg/kg, significantly reduced damage to sperm production and improved various biochemical markers, indicating that higher doses of CGA have better protective and therapeutic effects.
Background: Chlorogenic acid (CGA) is one of the well-known polyphenol compounds possessing several important biological and therapeutic functions. In order to optimize a culture system to achieve complete development of follicles, we focused on the effects of CGA supplementation during in vitro culture (IVC) on follicular development, oxidative stress, antioxidant capacity, developmental gene expression, and functional potential in cultured mouse ovarian tissue.
Methods And Results: The collected whole murine ovaries were randomly divided into four groups: (1) non-cultured group (control 1) with 7-day-old mouse ovaries, (2) non-cultured group (control 2) with 14-day-old mouse ovaries, (3) cultured group (experimental 1) with the culture plates containing only the basic culture medium, (4) cultured group (experimental 2) with the culture plates containing basic culture medium + CGA (50, 100 and 200 µmol/L CGA).
Article Synopsis
- Skin flap necrosis poses a significant challenge in plastic surgeries, prompting research into potential treatments.
- In a study with rats, three groups were given different doses of metformin after surgery to create a dorsal skin flap, with results showing improved survival rates in those treated with metformin.
- The low dose of metformin not only increased skin flap survival but also enhanced blood vessel density and the expression of vascular endothelial growth factor (VEGF) in the tissues, indicating better healing.
Aim: To investigate the effect of Propolis-gum Arabic as a nerve guidance channel.
Material And Methods: Male rats (n=24) were randomly divided into sham surgery, autograft, and Propolis+gum Arabic groups with equal numbers. Under anesthesia, the sciatic nerve was removed, and the gap between the two ending was repaired by Propolis-gum Arabic or nerve autograft.
Objectives: Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice.
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- This study aimed to assess the impact of various remote ischemic preconditioning (RIPC) techniques on spinal cord injury caused by ischemia-reperfusion in rats.
- A total of 36 rats were divided into six groups, and different RIPC methods were applied before inducing spinal cord ischemia, with evaluations conducted 72 hours post-injury to measure neurological function and tissue damage.
- The findings indicated that RIPC methods involving both hind and/or fore limbs improved motor function, reduced oxidative stress markers, and minimized white matter damage compared to the control group, suggesting these techniques offer protective benefits against spinal cord ischemic injuries.
Objectives: Paraplegia is deterioration in motor or sensory function of the lower limbs that can occur after modification of a thoracoabdominal aortic aneurysm. The purpose of this survey was to determine the protective action of lutein on spinal cord ischemia-reperfusion (I-R) damage.
Materials And Methods: Thirty-five male rats were distributed into five groups: intact, sham, dimethyl sulfoxide (I-R+DMSO), low dose lutein (I-R+0.
Background: Myocardial infarction is one of the most common life threatening diseases that may lead to renal disorders via oxidative stress and inflammation. Betaine is a safe and well-tolerated compound exhibiting beneficial antioxidant and anti-inflammatory properties. Previous studies have demonstrated protective effects of betaine against myocardial infarction and renal injury.
View Article and Find Full Text PDFObjective: To determine the effects of chicken embryo brain extract (BE) on transects sciatic nerve in male rats.
Methods: Thirty adult male Sprague-Dawley rats weighing 200 to 250 g, were randomized into three groups treated with (1) sham surgery, (2) normal saline (NS), and (3) brain extract (BE). The BE was taken from incubating chick embryos at day 8.
Article Synopsis
- The study examines the protective effects of spinach extract against spinal ischemia/reperfusion injury, which can lead to paraplegia or paraparesis after thoraco-abdominal aorta surgery.
- Thirty-five male Sprague-Dawley rats were divided into groups to assess neurological function and biochemical markers 72 hours post-ischemia.
- Results showed that rats treated with spinach extract had better motor function, higher antioxidative capacity, and preserved motor neurons compared to the normal saline control group.
Myocardial infarction is commonly considered as a leading cause of cardiovascular disease taking the lives of seven million people annually. Liver dysfunction is associated with cardiac diseases. The profile of abnormal liver functions in heart failure is not clearly defined.
View Article and Find Full Text PDFObjectives: When the nerve is injured near its entrance to the muscle belly, we cannot perform conventional methods. One useful method in such a situation is neurotization surgery. In this study, Bone marrow mesenchymal stem cells (BMSCs) implanted into the paralyzed muscle after neurotization surgery.
View Article and Find Full Text PDFAtherosclerosis could be deemed as a chronic, progressive, and inflammatory disease. It has been well-documented that high-density lipoprotein (HDL) can reduce the risk of the atherosclerosis occurrence through exerting some anti-atherogenic mechanisms. In recent years, the strong evidence has suggested that paraoxonase 1 (PON1) may contribute to antioxidant properties of HDL.
View Article and Find Full Text PDFA recent hypothesis has revealed that low-dose irradiation (LDI) with ionizing radiation might have a promoting effect on fracture healing. The aim of this study was to investigate the influence of direct (electron beam) and indirect (gamma-ray) low-dose ionizing irradiations on the wound healing process in male rats. In 72 male rats, a full-thickness wound was incised.
View Article and Find Full Text PDFPurpose: Skin flap necrosis due to inadequate blood supply has remained a common postoperative problem in constructive surgery. As low-dose irradiation (LDI) has been shown to promote the wound-healing process, this study aims to investigate whether LDI could increase neovascularization and skin flap survival in rats.
Methods: McFarlane flaps were created in 21 male rats, which were divided into one control and two treatment groups (Ta and Tb).
Objectives: Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury.
Materials And Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract.
Article Synopsis
- The study aimed to compare the effects of cerebrospinal fluid (CSF) and autograft on nerve regeneration within a collagen channel.
- Forty adult male rats were divided into four groups: collagen channel with CSF, collagen channel with saline, autograft, and a sham surgery group, with evaluations based on sciatic functional index (SFI) and other tests.
- Results showed that the CSF group had significantly better functional recovery and nerve conduction compared to the autograft group, indicating that CSF enhances nerve regeneration in the injured sciatic nerve.
Objective(s): The aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (ESM) tube conduit in comparison with autograft.
Materials And Methods: Thirty adult male rats (250-300 g) were randomized into (1) ESM conduit, (2) autograft, and (3) sham surgery groups. The eggs submerged in 5% acetic acid.