sp. Nov., a Soil Myxobacterium Isolated from Subtropical Climate, Chalus County, Iran, and Its Potential to Produce Secondary Metabolites.

A novel myxobacterial strain ZKHCc1 1396 was isolated in 2017 from a soil sample collected along Chalus Road connecting Tehran and Mazandaran, Iran. It was a Gram-negative, rod-shaped bacterial strain that displayed the general features of including gliding and fruiting body formation on agar and microbial lytic activity. Strain ZKHCc1 1396 was characterized as an aerobic, mesophilic, and chemoheterotrophic bacterium resistant to many antibiotics.

Combination and improvement of conventional DNA extraction methods in Actinobacteria to obtain high-quantity and high-quality DNA.

Background And Objectives: DNA extraction is an important step of any molecular experiment. DNA could not be easily extracted from members of actinomycetes by the usual methods of lysis. Due to the low efficiency of the conventional DNA extraction methods, development of an effective technique for DNA extraction of actinobacteria in emergency cases seems to be necessary.

Isolation and identification of the bacterium producing antitumor and antimicrobial compounds derived from Iranian swamp frog skin.

Background And Objectives: Cancer incidence and recurrence, antibiotic resistance, and overuse of antibiotics have become a global concern. The purpose of this study was to identify and isolate bacteria from the skin of the , Iranian swamp frog, which has produced antimicrobial compounds, and investigate its cytotoxic activity on the breast (MCF7) and glioblastoma (U87) cancer cell line.

Materials And Methods: An antibiotic-producing bacterium was isolated from the frog skin.

Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis.

The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.

Isolation, Partial Purification and Characterization of an Antimicrobial Compound, Produced by Bacillus atrophaeus.

Background: Antibiotics are usually assumed as secondary metabolites produced during the idiophase of microbial growth, which can kill or inhibit the growth of other microorganisms. Nowadays, indiscriminate use of antibiotics has resulted in resistant microorganisms. Therefore, screening researches on products with antimicrobial activities are necessary.