Novel Oleanolic Acid-Phtalimidines Tethered 1,2,3 Triazole Hybrids as Promising Antibacterial Agents: Design, Synthesis, In Vitro Experiments and In Silico Docking Studies.

As part of the valorization of agricultural waste into bioactive compounds, a series of structurally novel oleanolic acid ((3β-hydroxyolean-12-en-28-oic acid, )-phtalimidines (isoindolinones) conjugates - bearing 1,2,3-triazole moieties were designed and synthesized by treating an azide previously prepared from isolated from olive pomace ( L.) with a wide range of propargylated phtalimidines using the Cu(I)-catalyzed click chemistry approach. and its newly prepared analogues, - were screened in vitro for their antibacterial activity against two Gram-positive bacteria, and , and two Gram-negative bacteria, and .

Chemical Composition and Cytotoxic Activity of Eucalyptus torquata Luehm. and Eucalyptus salmonophloia F. Muell. Trunk Bark Essential Oils against Human SW620 and MDA-MB-231 Cancer Cell Lines.

In recent years, there has been a growing interest in the screening of natural active ingredients from Eucalyptus essential oils because of their evident importance in practical utility and their undeniable therapeutic properties. Based on this, the aim of the present study was to investigate the chemical profile of the essential oils of the trunk bark of Eucalyptus torquata Luehm. (ETEO), and E.