Publications by authors named "Ghofrane Barka"
We propose that peptides are highly versatile platforms for the precise design of supramolecular metal architectures, and particularly, for the controlled assembly of helicates. In this context, we show that the bacteriophage T4 Fibritin foldon (T4Ff) can been engineered on its N-terminus with metal-chelating 2,2'-bipyridine units that stereoselectively assemble in the presence of Fe(II) into parallel, three-stranded peptide helicates with preferred helical orientation. Modeling studies support the proposed self-assembly and the stability of the final helicate.
View Article and Find Full Text PDFSelective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides.
Chem Commun (Camb)
January 2018
Article Synopsis
- A new set of Ru(ii) metallopeptides with the dppz ligand was created using Solid Phase Peptide Synthesis (SPPS) techniques.
- The presence of an octaarginine tail significantly enhances the binding affinity of these metallopeptides to DNA G-quadruplex structures compared to those without the tail, highlighting the importance of both the tail and ancillary ligand in the recognition process.
- These oligoarginine metallopeptides are effectively taken up by cells and lead to cell death, exhibiting characteristics of apoptosis.