Tropisetron and paracetamol association in post-operative patients.

Studies in animals and in healthy volunteers have demonstrated the central serotonergic analgesic mechanism of action of paracetamol involving the inhibition of this analgesia by tropisetron, a 5-HT3 antagonist. This randomized, double-blind, controlled study aims at studying this interaction in post-operative patients after ear surgery. Thirty-six patients are included in two parallel groups with intravenous paracetamol (1 g) and either tropisetron (T, 5 mg/mL) or placebo (c, NaCl 0.

Comparison of a functional restoration program with active individual physical therapy for patients with chronic low back pain: a randomized controlled trial.

Objective: To compare the short-term outcomes of active individual therapy (AIT) with those of a functional restoration program (FRP).

Design: Prospective randomized controlled study.

Setting: Two rehabilitation centers and private ambulatory physiotherapy facilities.