Publications by authors named "Ghislaine F Taubman"
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, and incurable neurodegenerative disease. Recent studies suggest that dysregulation of gene expression by microRNAs (miRNAs) may play an important role in ALS pathogenesis. The reversible nature of this dysregulation makes miRNAs attractive pharmacological targets and a potential therapeutic avenue.
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- Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease influenced by genetic, epigenetic, and environmental factors, with the gut microbiome recently being implicated as well.
- A study utilizing a mutant SOD1 mouse model revealed early changes in the gut microbiome, followed by motor dysfunction, muscle atrophy, and immune cell activation, particularly in the spinal cord.
- The findings highlight the complex interplay between gut microorganisms and the immune system, paving the way for potential new biomarkers and treatments for ALS.