Publications by authors named "Ghislain Mpandzou"
To determine the prevalence of the rhythmic disorders during ischemic stroke, and to identify the predictive factors of paroxysmal atrial fibrillation (PAF). It was about a cross-sectional study, descriptive and analytical, conducted to Brazzaville between january 2012 and december 2016. It related to a consecutive series of 267 patients victims of a transient ischemic attack (n = 17) or ischemic stroke (n = 250), documented by cerebral tomodensitometry or brain MRI.
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- Arginase serum levels are elevated in patients with human African trypanosomiasis but normalize after treatment.
- Arginase breaks down l-arginine into l-ornithine, which is crucial for the growth of the parasite causing the disease.
- Decreased l-arginine can weaken immune responses, suggesting that arginase levels could serve as a marker for how effective the treatment is.
Gambian (Trypanosoma brucei gambiense) human African trypanosomiasis (HAT) evolves from the hemolymphatic stage 1, treated with pentamidine, to the meningoencephalitic stage 2, often treated with melarsoprol. This arseniate may provoke a deadly reactive encephalopathy. It is therefore crucial to diagnose precisely the stages of HAT, especially when clinical and biological examinations are doubtful.
View Article and Find Full Text PDFObjectives: In human African trypanosomiasis (HAT, sleeping sickness), staging of disease and treatment follow-up relies on white cell count in the cerebrospinal fluid (CSF). As B lymphocytes (CD19 positive cells) are not found in the CSF of healthy individuals but occur in neurological disorders such as multiple sclerosis, B lymphocyte count may be useful for field diagnosis/staging and therapeutic follow-up in HAT.
Methods: Seventy-one HAT patients were diagnosed and 50 were followed-up 6-24 months after treatment.