Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of (Fabaceae).

The chemical investigation of the leaves and stem bark of (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound and the analogues as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes.

Polyphenols: a diverse class of multi-target anti-HIV-1 agents.

Polyphenols are a versatile class of compounds that represent secondary metabolites from higher plants and which are abundantly present in the human diet. Epidemiological data suggest protective effects of polyhenols in relation to cancer, cardiovascular diseases, diabetes, infectious diseases and age-related conditions. HIV/AIDS remains prevalent in many parts of the world as acute infection and as anti-retroviral drug (ARV)-managed chronic disease.