Efficacy of rituximab in systemic manifestations of primary Sjogren's syndrome: results in 78 patients of the AutoImmune and Rituximab registry.

Objectives: To evaluate the efficacy and safety of rituximab in patients with primary Sjögren's syndrome (pSS).

Methods: The AutoImmune and Rituximab registry has included 86 patients with pSS treated with rituximab, prospectivey followed up every 6 months for 5 years.

Results: Seventy-eight patients with pSS (11 men, 67 women), who already had at least one follow-up visit, were analysed.

[Macroglobulinosis cutis revealing Waldenström macroglobulinemia].

Waldenström macroglobulinemia is defined by a bone marrow lymphoplasmacytic infiltration associated with serum IgM monoclonal gammopathy. Specific properties of the IgM gammopathy induce the main clinical manifestations revealing the disease: hyperviscosity syndrome, autoimmune peripheral neuropathy, cryoglobulinemia or hemolysis, and exceptional skin deposit such as macroglobulinosis cutis that we here report. Physicians should be aware of these clinical manifestations to avoid diagnostic delay.

[A case report of a recurrence of Mooren's ulcer after cataract surgery].

We report the case of Mooren's ulcer recurrence after uncomplicated cataract surgery in a 61-year-old woman. This cataract developed because of repetitive inflammation of the anterior chamber and corticotherapy. Local and general corticotherapy with cyclosporin 2% drops was started in association with an anterior lamellar graft and a conjunctival recession due to a preperforation condition.

[Exophtalmia revealing a mantle cell lymphoma].

Introduction: Mantle cell lymphoma reached rarely ophtalmic sphere and salivary glands. CAS REPORT: We reported a dry syndrome seen in a 67 year-old patient. The first patological analysis of accessory salivary glands evoked a primary Gougerot-Sjögren syndrome.

[Pulmonary plasmacytoma: about two new cases and review of the literature].

Introduction: Extramedullary plasmacytoma is an uncommon plasma cell malignancy mainly located to the upper aerodigestive tract. Primary pulmonary plasmacytoma is extremely rare.

Exegesis: We report two new cases of primary pulmonary plasmacytoma and then proceed to a review of the literature concerning 35 similar cases previously described.

Transfusional Mansonella perstans microfilariasis.

Mansonella perstans filariasis is widely distributed across the center of Africa and equatorial America. We describe a case of post-transfusional M. perstans microfilariasis in a young child, affected with severe Plasmodium falciparum malaria, admitted in Goundi Hospital in South of Chad.

Case report: intraocular localization of Mansonella perstans in a patient from south Chad.

A case of Mansonella perstans infection with visual impairment and a retinal lesion is described. After a course of diethylcarbamazine and a further course of mebendazole the symptoms improved and the microfilariae blood concentration decreased. The symptoms and response to antifilarial treatment strongly suggested the intraocular localization of an M.

Indications and results of the surgical treatment in Raynaud's phenomenon.

203 patients submitted in the last 20 years to surgery, first by Smithwick's sympathectomy, then by Adson's gangliectomy and lastly by Telford's gangliectomy, were controlled. The frequency of true Raynaud's disease is with time decreasing and is found today in the minority of the patients suffering from Raynaud's phenomenon and surgically treated. Immunological tests detect frequent associated autoimmune disorders to be treated before surgery.