Publications by authors named "Ghina Bouabout"
Background: The development of new non-surgical treatments dedicated to mitral valve degeneration is limited by the absence of relevant spontaneous and rapidly progressing animal experimental models.
Animals: We characterized the spontaneous mitral valve degeneration in two inbred FVB mouse strains compared to C57BL/6J and investigated a contribution of the serotonergic system.
Methods: Males and females FVB/NJ and FVB/NRj were compared to the putative C57BL/6J control at 12, 16, 20 and 24 weeks of age.
Article Synopsis
- Metabolic syndrome involves issues like obesity, high blood pressure, and glucose intolerance, with oxidative stress playing a key role in these conditions.
- The study aimed to see if blocking the Nox4 enzyme could help improve blood pressure and metabolic issues in mice on a high-fat diet or receiving angiotensin II injections.
- Results showed that Nox4 inhibition had protective effects against blood pressure increases and reduced triglycerides in normal diet conditions, but it did not prevent heart damage or improve outcomes on a high-fat diet, especially worsening glucose tolerance in female mice.
Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2) and R531G (AMPKγ2), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2 or AMPKγ2 leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype.
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