Publications by authors named "Gheorghita N"

A group of patients with moderate hypertension (149-150/90-99 mm Hg) performed physical exercise for 3 months; we determined the oxidative stress in blood samples, by calculating the level of some biochemical markers, non-enzyme antioxidants, glutathione (GSH), total -SH groups (G-STH), nonprotein -SH groups (G-SHNP), their G-SHT/G-SHNP ratio, uric acid, malondialdehyde (MDA) and comparing the results with the values obtained from a group of healthy subjects. We found an increased oxidative stress at the HTA patients, with initial (Vi) decreasing values of GSH and uric acid, and with higher values of MDA. After the 3 months (Vf) of physical training, the oxidative stress improved, with increasing GSH, uric acid and decreasing MDA, compared to normal subjects.

View Article and Find Full Text PDF

A group of patients with moderate hypertension (149-150/90-99 mmHg) performed physical exercise for 3 months; we determined the oxidative stress in blood samples, by calculating the level of some antioxidative markers, the enzymes SOD, CAT, GPx, MDA and comparing the results with the values obtained from a group of healthy subjects. We found an increased oxidative stress at the hypertensive patients, with initial higher values of SOD and MDA and with lower values of CAT and GPx, compared to the normal subjects. After the 3 months of physical training, the oxidative stress improved, with decreasing activity of SOD, GPx, MDA and increasing CAT, maintaining the ratio CAT/SOD and GPx/SOD superior compared to normal subjects.

View Article and Find Full Text PDF

We have studied a macromolecular prodrug that contains nicotinic acid bound on a polymeric support of dextran. We have determined plasmatic levels of nicotinic acid, by a HPLC method, after macromolecular conjugate administration for a 24 hours period. In order to study the hypolipidemic effect, triglyceride levels were determined and correlated with plasmatic levels of nicotinic acid.

View Article and Find Full Text PDF

The evaluation of the results of the oxygen free radicals (RLO2) formation is a current subject in biology and medicine. The oxidative stress, which is the altering of the balance between the higher activity of oxygen and the enzymatic or nonenzymatic protection systems, may be one of the causes that starts and aggravates a disease. In this context, the supplementation of the diet with selenium, superoxide dismutase, vitamins A, C, E, is considered a primary prevention measure (for the apparently healthy persons) and a secondary one (for those with advancing forms of disease) that is both efficient and modern by utilization of some "drug-food" products.

View Article and Find Full Text PDF

The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR.

View Article and Find Full Text PDF

The results of a pluridisciplinary epidemiological study carried out on a series of 225 adults from rural areas, in whom the prevalence of arterial hypertension disease (AHTD) and borderline (AHTB) was of 19.0% and 14.4%, respectively, are presented.

View Article and Find Full Text PDF

The increased efficiency of epidemiological screening tests in determining the prevalence of risk factors carriers required the use of highly sensitive markers able at detecting early, in reversible stages, the disturbances in the lipid metabolism genetically induced or acquired during lifetime, known as major risk factors for essential hypertension and other cardiovascular diseases. The authors report the preliminary results of some investigations on the predictive value of apolipoproteins. Immunokits manufactured by BioMérieux--France were used.

View Article and Find Full Text PDF

Objectives: The aim of the study is to follow the variation of some parameters of the lipidic metabolism, during physical training, at patients with chronic myocardial infarction.

Methods: Among 132 patients with chronic myocardial infarction, we selected 22 patients, mean age 47.4 +/- 6.

View Article and Find Full Text PDF

The professional poisoning with acrylonitrile of some subjects induced a significant decrease of reduced glutathione (81.30%), redox ratio reduced glutathione/oxidized glutathione (90.74%) and "Benzi-redox index" (55.

View Article and Find Full Text PDF

In the animals with a 24 hours and 15 days transplant of Guérin lymphotropic epithelioma Nystatin MC in a dose of 800 mg/K body weight/day and 1 800 mg/K body weight/day every 3 and 6 hours daily for 8 days was injected subcutaneously. The dosing of the activity of gluthamin-synthetase, MDH and catalase in tumours of 8, 23, and 38 days showed that Nystatin MC disturbed the activity of the enzymes from mythocondries and cytoplasm especially in the 8 and 23 days tumours, influencing the glycolitic process. The gluthamin-synthesis was inhibited during the entire tumoral activity period, reaching after treatment almost normal values.

View Article and Find Full Text PDF

After 30 years of iodine prophylaxis the incidence of goiter in the Valea Jiului area was reassessed. A number of 7,892 pupils aged 7-16 years were examined, of whom goiter was found in 32%. Before iodine prophylaxis started the incidence was 91.

View Article and Find Full Text PDF