Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration.

Cyclodextrins (CDs) are known for their ability to extract lipid components from synthetic and biological membranes and therefore to induce an increase of membrane permeability. However, the effect of cholesterol (CHOL) content in the membrane on the CD permeabilizing effect was not considered yet. Given that an increase in CHOL content reduces the membrane permeability, the aim of this work was to reveal how CHOL would modulate the CDs effect on the membrane.

Liposome Permeability to Essential Oil Components: A Focus on Cholesterol Content.

Encapsulation in liposomes has been an efficient strategy to improve the stability of sensitive bioactive compounds such as essential oils (EOs). However, the stability of liposomal formulations remains a key parameter controlling the delivery of encapsulated ingredients. Cholesterol (Chol) modulates the membrane properties conferring stability to the lipid bilayer.

Liposomal membrane permeability assessment by fluorescence techniques: Main permeabilizing agents, applications and challenges.

Liposomes are lipid vesicles made of one or multiple lipid bilayers surrounding an internal aqueous core. They are broadly employed as models to study membrane structure and properties. Among these properties, liposome membrane permeability is crucial and widely assessed by fluorescence techniques.