Publications by authors named "Ghazi Dhoot"
Article Synopsis
- - Beta-thalassemia is a genetic disorder that leads to reduced red blood cell lifespan and severe anemia due to an imbalance in hemoglobin chains, primarily affecting the adult beta-globin chain.
- - Current treatments include regular blood transfusions and chelation therapy to manage iron overload, with newer strategies exploring fetal hemoglobin switching to improve red blood cell survival.
- - In a study involving 21 beta-thalassemia patients, autologous retrodifferentiated stem cell infusions significantly reduced transfusion needs, increased fetal hemoglobin production, and improved various blood parameters over a six-month period.
Severe combined immunodeficient (SCID)-repopulating cells (termed SRC) with lymphohaematopoietic differentiation potential reside at an extremely low frequency in unmobilised adult human peripheral blood. Recently, an ex vivo method of increasing the relative numbers of at least four distinct human stem cell classes, that include CD34+ haematopoietic progenitor cells, in mononuclear cells (MNC) obtained from unmobilised adult human peripheral blood has been described. This process is triggered by a monoclonal antibody (mAb) against the human monomorphic region of the beta chain of HLA-DP, DQ and DR (clone CR3/43).
View Article and Find Full Text PDF