Publications by authors named "Ghazel Mukhtar"
Article Synopsis
- Public space initiatives (PSIs) in African cities can improve health and social well-being, but there's a lack of research on their effectiveness and implementation across the continent.
- This study synthesizes existing literature to assess the characteristics, locations, and outcomes of PSIs, finding that sports initiatives are predominant and that most research comes from South Africa.
- Key challenges for PSIs include limited funding, historical marginalization, and competing land uses, highlighting the need for long-term evaluations and better collaboration for sustainable health-promoting public spaces.
Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia inherited as an autosomal dominant trait, due to a single heterozygous loss-of-function variant, usually in (encoding activin receptor-like kinase 1 [ALK1]), (encoding endoglin [CD105]), or . In a consecutive single-centre series of 37 positive clinical genetic tests performed in 2021-2023, a skewed distribution pattern was noted, with 30 of 32 variants reported only once, but c.1231C>T (p.
View Article and Find Full Text PDFHereditary haemorrhagic telangiectasia (HHT) can result in challenging anaemia and thrombosis phenotypes. Clinical presentations of HHT vary for relatives with identical casual mutations, suggesting other factors may modify severity. To examine objectively, we developed unsupervised machine learning algorithms to test whether haematological data at presentation could be categorised into sub-groupings and fitted to known biological factors.
View Article and Find Full Text PDFArticle Synopsis
- Q fever is a zoonotic disease caused by a specific bacterium, and the Q-VAX vaccine can cause significant side effects, leading researchers to study the immune reactions of individuals with different exposure histories to the disease.
- The study analyzed cytokine responses from three groups: Dutch blood donors with unknown exposure, villagers with known past exposure during a Q fever outbreak, and Australian students vaccinated with Q-VAX, measuring various immune markers after stimulation with the bacterium.
- Results showed that individuals with prior exposure had stronger immune responses, particularly in certain cytokines, and the study identified distinct immune response patterns among the groups, but a clear link between prior exposure and specific immune signatures couldn't be established.