The combined effects of ethanolic extract of and on biofilm genes expression of methicillin resistant .

Background And Objectives: One of the most important antibiotic-resistant bacteria is methicillin-resistant (MRSA) biofilm that has caused significant problems in treating the patients. Therefore, the aim of this study was to evaluate the levels of expression of genes involved in biofilm formation in MRSA (ATCC 33591) while being treated by a combination of and .

Materials And Methods: The minimum inhibitory concentration (MIC) of ethanolic extract of and and also the minimum inhibitory concentration of combination of both extracts were 512, 1024 and 256 μg/ml, respectively; then at concentrations lower than the MIC, expression levels of the desired genes were determined by Real Time PCR.