Simple three-component method for the synthesis of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3'-indolines.

An efficient, simple, and catalyst-free synthesis of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3'-indolines and spiroacenaphthylene-1,4'-indeno-1,5'-pyrido[2,3-d]pyrimidines by the three-component reaction of 1,3-indandione, amino uracils and isatins or acenaphthylene-1,2-dione in refluxing ethanol is reported.

Three-component synthesis of 2-oxoindolin-3-ylphosphonates.

A one-pot, three-component and catalyst-free method for the efficient and simple synthesis of dialkyl 3-(dicyanomethyl)-2-oxoindolin-3-ylphosphonates at 50 degrees C under solvent-free conditions is reported. The features of this procedure are mild reaction conditions, high yields of products, and operational simplicity.

Simple and catalyst-free synthesis of oxoindolin-3-yl phosphonates.

An efficient, simple, and catalyst-free synthesis of dialkyl or diaryl 3-(dicyanomethyl)-2-oxoindolin-3-ylphosphonates by the reaction of dialkyl or diaryl phosphites and oxoindolin-3-ylidenemalononitriles under solvent-free conditions is reported. The reaction of imino isatins with dialkyl or diaryl phosphites results in the formation of dialkyl or diaryl 2-oxo-3-(arylamino)indolin-3-ylphosphonates.

One-pot, pseudo four-component synthesis of a spiro[diindeno[1,2-b:2',1'-e]pyridine-11,3'-indoline]-trione library.

A one-pot, pseudo four-component method for the efficient and simple synthesis of spiro[diindeno[1,2-b:2',1'-e]pyridine-11,3'-indoline]-2',10,12-trione derivatives in refluxing acetonitrile is reported. The features of this procedure are mild reaction conditions, high yields of products, and operational simplicity.