Publications by authors named "Ghazaleh E Pourmahram"
Reactive oxygen species play a key role in vascular disease, pulmonary hypertension, and hypoxic pulmonary vasoconstriction. We investigated contractile responses, intracellular Ca(2+) ([Ca(2+)](i)), Rho-kinase translocation, and phosphorylation of the regulatory subunit of myosin phosphatase (MYPT-1) and of myosin light chain (MLC(20)) in response to LY83583, a generator of superoxide anion, in small intrapulmonary arteries (IPA) of rat. LY83583 caused concentration-dependent constrictions in IPA and greatly enhanced submaximal PGF(2alpha)-mediated preconstriction.
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- Reactive oxygen species, like hydrogen peroxide, play a role in causing vasoconstriction in intrapulmonary arteries (IPAs) and affect calcium levels in these arteries.
- Peroxide induced both transient and sustained vasoconstriction, with the transient phase being influenced by certain inhibitors, while sustained constriction seemed to rely on calcium release from internal stores.
- The study revealed that the mechanism of sustained constriction involves protein kinase C (PKC) activity rather than the Rho kinase pathway and does not significantly impact the phosphorylation of specific myosin light chain proteins.