2,2,7,7,12,12,17,17-Octa-methyl-21,22,23,24-tetra-thia-2,7,12,17-tetra-germapenta-cyclo-[16.2.1.1(3,6).1(8,11).1(13,16)]tetra-cosa-3,5,8,10,13,15,18,20-octa-ene.

The title compound, [Ge4(CH3)8(C4H2S)4], crystallizes with one-half mol-ecule in the asymmetric unit, the whole mol-ecule being generated by inversion symmetry. The dihedral angle between adjacent thio-phene rings is 72.84 (14)°.

Synthesis and antioxidant properties of pulvinic acids analogues.

The synthesis of three types of pulvinic acid analogues, using a diversity-oriented strategy starting from a single compound, dimethyl l-tartrate, is described. Lacey-Dieckmann condensation, alcohol dehydration and Suzuki-Miyaura cross-couplings were employed in the course of the analogues syntheses. The evaluation of the antioxidant properties of the 28 synthesized analogues was carried out using antioxidant capacity assays (protection of thymidine and β-carotene) and free radical scavenging assays (DPPH radical and ABTS radical cation).

Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.

In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modifications on these skeletons affected the antioxidant activity. Thiol and aminothiol compounds derived from thiadiazoles and benzothiazoles showed an interesting antioxidant property.

Evaluation of new thiadiazoles and benzothiazoles as potential radioprotectors: free radical scavenging activity in vitro and theoretical studies (QSAR, DFT).

Thiol and aminothiol compounds are among the most efficient chemical radioprotectors. To increase their efficiency, we synthesized two new classes of thiol and aminothiol compounds derived from benzothiazole (T1, T2, AM1, AM2) and thiadiazole (T3, T4, AM3) structures. We examined them for their ability to scavenge free radicals (DPPH*, ABTS(*+), *OH).

Evaluation, in vitro, of the radioprotection of DNA from gamma-rays by naphazoline.

Design of compounds that can protect efficiently against gamma-rays irradiation is a great challenge. An ionizing event can cause variety of DNA damage scenarios leading to mutagenesis, cell death. 2-(1-Naphthylmethyl)-2-imidazoline (naphazoline, NP) is a drug belonging to the vasoregulator class, which was shown to be a very interesting compound in radioprotection.