Effects of time-restricted feeding (TRF)-model of intermittent fasting on adipose organ: a narrative review.

Time-restricted feeding (TRF), an intermittent fasting approach involving a shortened eating window within 24 h, has gained popularity as a weight management approach. This review addresses how TRF may favor fat redistribution and the function of the adipose organ. TRF trials (mainly 16:8 model, with a duration of 5-48 weeks) reported a significant weight loss (1.

An Survey on the Effect of Six Commercial Brands of Phosphoric Acid on the Micro-shear Bond Strength of Composite Resin to Enamel.

Statement Of The Problem: One of the most important factors in the clinical longevity of composite resin restorations is proper adhesion, which is achieved using phosphoric acid. Different phosphoric acid products might affect the micro-shear bond strength of composite resin to enamel.

Purpose: The present study aimed to evaluate the micro-shear bond strength of composite resin to sound enamel using six different brands of acid-etch agents.

Brain glucose metabolism: Role of nitric oxide.

One possible reason for failure in achieving optimal glycemic control in patients with type 2 diabetes (T2D) is that less attention has been paid to the brain, a fundamental player in glucose homeostasis, that consumes about 25% of total glucose utilization. In addition, animal and human studies indicate that nitric oxide (NO) is a critical player in glucose metabolism. NO synthesis from L-arginine is lower in patients with T2D, and endothelial NO synthase (eNOS)-derived NO bioavailability is lower in T2D.

Excessive exposure to nitrate and nitrite boosts progression of isolated impaired fasting glucose to type 2 diabetes: a cohort study.

Objectives: This cohort study investigated the possible association of dietary nitrate (NO)/nitrite (NO) intake and risk of progression to type 2 diabetes (T2D) across different phenotypes of prediabetes (Pre-DM).

Methods: A total of 1586 adults diagnosed with Pre-DM [i.e.

Type 2 diabetes-related sarcopenia: role of nitric oxide.

Sarcopenia, characterized by progressive and generalized loss of skeletal muscle (SkM) mass, strength, and physical performance, is a prevalent complication in type 2 diabetes (T2D). Nitric oxide (NO), a multifunctional gasotransmitter involved in whole-body glucose and insulin homeostasis, plays key roles in normal SkM physiology and function. Here, we highlight the role of NO in SkM mass maintenance and its potential contribution to the development of T2D-related sarcopenia.

Beginning at the ends: telomere and telomere-based cancer therapeutics.

Telomeres, which are situated at the terminal ends of chromosomes, undergo a reduction in length with each cellular division, ultimately reaching a critical threshold that triggers cellular senescence. Cancer cells circumvent this senescence by utilizing telomere maintenance mechanisms (TMMs) that grant them a form of immortality. These mechanisms can be categorized into two primary processes: the reactivation of telomerase reverse transcriptase and the alternative lengthening of telomeres (ALT) pathway, which is dependent on homologous recombination (HR).

Comparison of the effects of deferasirox film-coated tablets (Jadenu) and deferasirox dispersible tablets (Exjade) in patients with beta thalassemia major: a preliminary report of the effects on the satisfaction, convenience, cardiac/liver MRI T2*, serum ferritin level, and biochemical profiles.

Background: Deferasirox (DFX) is a once-daily oral iron chelator with proven dose-dependent efficacy in patients with thalassemia major (TM). The reason for switching from DFX dispersible tablets (Exjade) to DFX film-coated tablets (Jadenu) was intolerance. Many patients also reported that deferasirox did not taste good.

Three Iranian patients with rare subtypes of hereditary spastic paraplegia (HSP): SPG76, SPG56, and SPG69.

Some subtypes of hereditary spastic paraplegia (HSP), especially with autosomal recessive inheritance (AR-HSP), have been reported rarely. In this study, we report the clinical features and molecular results of three unrelated Iranian patients with rare subtypes of HSP, including SPG76, SPG56, and SPG69; thereafter, we compare them to other reported cases. Three patients who were clinically diagnosed with HSP and born to consanguineous parents underwent molecular assessment by whole-exome sequencing (WES), followed by Sanger sequencing and co-segregation analysis.

Role of Balanced Involvement of the ICOS/ICOSL/Osteopontin Network in Cutaneous Wound Healing.

Inducible T-cell costimulator (ICOS, CD278) is a costimulatory receptor primarily expressed by activated T cells. It binds to ICOS ligand (ICOSL, CD275), which is expressed by various immune and non-immune cell types, particularly in inflamed tissues. ICOSL can also bind to osteopontin (OPN), a protein that functions both as a component of the extracellular matrix and as a soluble pro-inflammatory cytokine.

Clinical and genetic diversity in Iranian individuals with RAPSN-related congenital myasthenic syndrome.

Congenital myasthenic syndromes (CMSs) are genetic disorders affecting motor function with variable symptoms. RAPSN-related CMS, caused by mutations in the RAPSN gene, leads to muscle weakness. Accurate diagnosis is essential for proper management.

Effects of Dietary Taurine on Maturation Indices, Antioxidant Capacity, Ovaries Amino and Fatty Acids Profile, and Vitellogenin Gene Transcription Level in Female Brooders.

A 30-day research was carried out to examine the impacts of dietary taurine (Tau) on ovaries maturation and physiological responses of female brooders (29.4 ± 0.2 g).

Effect of Padzahr Tablet on Biochemical Indices of Bone Remodeling in Postmenopausal Females with Osteopenia: A Randomized Double-Blind Placebo-Controlled Trial.

Background: Osteoporosis is a complex disease that poses major global public health challenges. Many individuals with osteoporosis turn to complementary and alternative medicine (CAM) for prevention and management. Due to its mineral contents, Padzahr, a type of clay used in traditional Persian medicine, is believed to have bone-forming properties.

CHRNE-related congenital myasthenic syndrome in Iran: Clinical and molecular insights.

Variants in the CHRNE gene can lead to a condition called congenital myasthenic syndrome (CMS), which affects the neuromuscular junction (NMJ). CHRNE mutations are the most common cause of CMS. Seventy-seven patients with a possible diagnosis of CMS were referred to the neuromuscular clinic of Shariati Hospital affiliated with the Tehran University of Medical Sciences.

MR Imaging of Entrapment Neuropathies of the Hip.

Entrapment neuropathies of the hip (ENH) can occur due to a variety of causes with clinical symptoms that may mimic musculoskeletal disorders. Etiologies include entrapment in a fibromuscular canal, tethering due to posttraumatic fibrosis and extrinsic compression from muscle hypertrophy or a mass. Magnetic resonance (MR) imaging enables detection and characterization of peripheral nerve pathology.

Characteristics of optical coherence tomography in patients with iron deficiency anemia : a systematic review and meta-analysis.

Objective: The primary objective of this systematic review and meta-analysis was to assess the association between iron deficiency anemia (IDA) and retinal changes via optical coherence tomography (OCT).

Methods: The search was conducted in MEDLINE, Scopus, Embase, Web of Science, and Google Scholar until February 1, 2024. Two independent researchers included the articles based on the inclusion and exclusion criteria.

Effect of Educational Intervention by Application of PRECEDE-PROCEED Model on Lifestyle Change in Hypertensive Patients.

One of the most important causes of cardiovascular disease is hypertension. Lifestyle modification has been emphasized in preventing and controlling blood pressure. This research aimed to determine the effect of educational intervention by application of PRECEDE-PROCEED model on lifestyle change in hypertensive patients in the villages of Fasa City, Fars Province, Iran.

Study of pollution status in urban environment caused by attitude and waste littering behavior of citizens.

Littering behavior is one of the main challenges in waste management, especially in big cities. In this study, density and composition of litter in Tehran was investigated and the urban pollution status was calculated by using the clean environment index. The results showed that the average density of litter in the studied locations was 0.

Computational exploration of naturally derived peptides inhibitory mechanisms against ACE enzyme, from interactions to structural-dynamics.

Naturally derived peptides have gained significant attention because of their potential to reduce blood pressure. These peptides can be derived from various sources, including snake venom, marine organisms, cow's milk, seahorses, and plants. Investigating the underlying mechanisms of these peptides in lowering blood pressure is crucial for replacing synthetic drugs currently in use.

Three-Dimensional Magnetic Resonance Imaging in the Musculoskeletal System: Clinical Applications and Opportunities to Improve Imaging Speed and Resolution.

Although conventional 2-dimensional magnetic resonance (MR) sequences have traditionally comprised the foundational imaging strategy for visualization of musculoskeletal anatomy and pathology, the emergence of isotropic volumetric 3-dimensional sequences offers to advance musculoskeletal evaluation with comparatively similar image quality and diagnostic performance, shorter acquisition times, and the added advantages of improved spatial resolution and multiplanar reformation capability. The purpose of this review article is to summarize the available 3-dimensional MR sequences and their role in the management of patients with musculoskeletal disorders, including sports imaging, rheumatologic conditions, peripheral nerve imaging, bone and soft tissue tumor imaging, and whole-body MR imaging.

Nitric oxide-based treatments improve wound healing associated with diabetes mellitus.

Non-healing wounds are long-term complications of diabetes mellitus (DM) that increase mortality risk and amputation-related disability and decrease the quality of life. Nitric oxide (NO·)-based treatments (i.e.