Publications by authors named "Ghani A"

Article Synopsis
  • Inappropriate therapy (IAT) is a significant issue associated with implantable cardiac defibrillator (ICD) therapy, particularly highlighted in early subcutaneous ICD (S-ICD) studies which showed high rates of inappropriate shocks (IAS).
  • The PRAETORIAN trial, an international study with 849 patients, found no major differences in IAT and IAS rates between S-ICD and transvenous ICD (TV-ICD) groups, as both groups had similar cumulative incidences.
  • Key predictors for IAT varied between the two groups, with TV-ICD patients experiencing IAT mainly from supraventricular tachycardias, while S-ICD patients faced issues from cardiac oversensing
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Article Synopsis
  • The S-ICD was created to eliminate lead-related issues found in the TV-ICD, as it is an external device that sits under the skin rather than using leads inside the body.
  • This analysis comes from the PRAETORIAN trial, where patients were randomly assigned to either S-ICD or TV-ICD and assessed for quality of life through various questionnaires at different stages.
  • Results showed no significant differences in physical and mental well-being between the groups, but patients who experienced a shock recently reported lower social functioning and emotional health compared to those who did not.
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Metal ion intercalation into van der Waals gaps of layered materials is vital for large-scale electrochemical energy storage. Transition-metal sulfides, ABS (where A and B represent Zr, Hf, and Ti as monolayers as anodes), are examined as lithium and sodium ion storage. Our study reveals that these monolayers offer exceptional performance for ion storage.

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Interest in single-atom catalysts (SACs) has surged due to their potential to mitigate greenhouse NO gas from the environment. In this study, we explore the potential of NO reduction using porous 3D phosphorus graphdiyne decorated with an Al atom (3D-Al/PGDYN) through density functional theory. Results confirm the energetic stability of Al decorations on 3D-PGDYN and indicate that the Al atom plays an active role in catalysis.

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Background: The COVID-19 pandemic has underscored the beneficial impact of vaccines. It also highlighted the need for future investments to expedite an equitable vaccine distribution. The 100 Days Mission aims to develop and make available a new vaccine against a future pathogen with pandemic potential within 100 days of that pathogen threat being recognised.

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Gene drives are a promising means of malaria control with the potential to cause sustained reductions in transmission. In real environments, however, their impacts will depend on local ecological and epidemiological factors. We develop a data-driven model to investigate the impacts of gene drives that causes vector population suppression.

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Article Synopsis
  • - This study investigates how a specific surgical procedure (unilateral fronto-temporo-parietal decompressive craniectomy with dural expansion) impacts intracranial pressure (ICP) in patients with moderate to severe traumatic brain injury (TBI), emphasizing the role of bone flap size.
  • - A total of 52 TBI patients showed a significant average reduction of 56.7% in ICP post-surgery, with larger bone flaps (over 15 cm) associated with better, though not statistically significant, ICP control compared to smaller ones.
  • - The findings suggest that the surgery effectively reduces ICP, and using a bone flap of at least 12 cm is recommended for optimal outcomes, with better recovery observed particularly
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Background & objectives In gastrointestinal stromal tumour (GIST), not only genetic abnormalities are responsible for adverse clinical events, but epigenetic modifications also play a crucial role. MicroRNA (miRNA) dysregulation plays a significant role in carcinogenesis as miRNAs serve as natural silencer for their targets. Our study aimed to explore the miRNAs expression and its association with molecular and histopathological characteristics of GIST.

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The significance of cloud computing methods in everyday life is growing as a result of the exponential advancement and refinement of artificial technology. As cloud computing makes more progress, it will bring with it new opportunities and threats that affect the long-term health of society and the environment. Many questions remain unanswered regarding sustainability, such as, "How will widely available computing systems affect environmental equilibrium"? When hundreds of millions of microcomputers are invisible to each other, what will society look like? What does this mean for social sustainability? This paper empirically investigates the ethical challenges and practices of cloud computing about sustainable development.

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Automation is revamping our preprocessing pipelines, and accelerating the delivery of personalized digital medicine. It improves efficiency, reduces costs, and allows clinicians to treat patients without significant delays. However, the influx of multimodal data highlights the need to protect sensitive information, such as clinical data, and safeguard data fidelity.

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Chiari malformation type 1 (CM 1) entails a structural defect in the cerebellum, involving the herniation of cerebellar tonsils toward the foramen magnum. The symptomatic or asymptomatic nature of CM 1 is contingent upon the condition of malformation in the spinal cord. This review presents an updated perspective on the prevalence of CM 1, its pathogenesis, genetic associations, and treatment.

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The Internet of Things (IoT) generates substantial data through sensors for diverse applications, such as healthcare services. This article addresses the challenge of efficiently utilizing resources in resource-scarce IoT-enabled sensors to enhance data collection, transmission, and storage. Redundant data transmission from sensors covering overlapping areas incurs additional communication and storage costs.

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This research is focused on the development of an eco-friendly low-cost concrete using fly ash (FA) and marble powder waste (MPW) as partial replacements for cement and fine aggregate respectively. The substantial use of cement in concrete makes it expensive and contributes to global warming due to high carbon emissions. Thus, using such waste materials can help reduce the overall carbon footprint.

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Spontaneous coronary artery dissection (SCAD) has been increasingly recognized in recent years as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, especially among young women. However, due to the lack of clinical trials on SCAD, evidence-based guidance on management is currently lacking. Presented are four case studies that illustrate the recent insights and challenges in SCAD diagnosis and treatment.

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Background: Transcatheter aortic valve replacement (TAVR) can be complicated by anemia due to periprocedural bleeding, hemolysis, vascular events, or significant bleeding associated with antiplatelet therapy.

Objective: We used the National Inpatient Sample (NIS) database to study the outcomes of patients who underwent TAVR and developed significant anemia requiring red blood cell (RBC) transfusion.

Methods: This is a retrospective cohort study utilizing the NIS database from 2016 to 2017.

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Pakistan's economy greatly benefits from citrus production since these fruits are sold and consumed all over the world. Although citrus fruits are easy to cultivate, they are susceptible to diseases caused by bacteria, viruses, and fungi. These challenges, as well as difficulties in obtaining the proper nutrients, might negatively impact fruit yields and quality.

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Background: Severe traumatic brain injury (TBI) is a leading cause of disability worldwide and cerebral protection (CP) management might determine the outcome of the patient. CP in severe TBI is to protect the brain from further insults, optimise cerebral metabolism and prevent secondary brain injury. This study aimed to analyse the short-term Glasgow Outcome Scale (GOS) at the intensive care unit (ICU) discharge and a month after ICU discharge of patients post CP and factors associated with the favourable outcome.

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Article Synopsis
  • Light is an electromagnetic radiation with both visible and invisible spectrums, only detectable by the eyes and shielded from direct exposure to the brain by the scalp and cranium.
  • The brain functions like a black body in thermal equilibrium, suggesting it shouldn't be exposed to light, yet photobiomodulation therapy shows potential benefits for neurological conditions.
  • In a study during awake brain surgery, different light wavelengths caused rapid electrocorticographic brainwave changes, indicating that light can significantly influence brain energy and function through a proposed plasma-like energy mechanism.
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Multiple sclerosis (MS) is a multifactorial polygenic disease; results from autoimmune and neurodegenerative processes which lead to multifocal lesions of the central nervous system. Axonal degeneration was found to be prominent in the inflammation period of MS and contribute to the progression of disability. Soluble N-ethylmaleimide sensitive factor attachment receptor (SNARE) complex plays a vital role in the release of neurotransmitter by synaptic vesicle fusion.

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The lumbar plexus provides innervation to the lower limbs and is essential in enabling motor movement and sensation in the lower limbs. Some of its branches also innervate the muscles in the pelvic girdle. Compared to the brachial plexus in the upper limbs, the lumbar plexus appears to garner less recognition among physicians and surgeons.

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In the present study, the oxidative stability and antioxidant activity of seed oils were investigated in three Iranian pomegranate cultivars, Shirin Khafr, Torsh Sabz, and Rabab, along with the sesame ( L. cv Dezful) seed oil. Punicic acid was the primary fatty acid in the pomegranate seed oils, with contents ranging from 75.

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Covalent organic frameworks can be used for next-generation rechargeable metal-ion batteries due to their controllable spatial and chemical architectures and plentiful elemental reserves. In this study, the arsenic-based covalent organic framework (As-COF) is designed by employing the geometrical symmetry of a semiconducting phosphazene-based covalent organic framework that uses -phenylenediamine as a linker and hexachorocyclotriphosphazene as an As-containing monomer in a -like spatial configuration. The As-COF with engineered nanochannels demonstrates exceptional anodic behavior for potassium (K) and calcium (Ca) ion batteries.

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