Autonomic functions, tinnitus annoyance and loudness, and quality of life: Randomized-controlled responses to bee-humming (vibrational) respiratory training in tinnitus elderly.

Background: In chronic subjective tinnitus (CST) studies, the effect of bee-humming respiratory training (BHRT), a type of pranayama breathing technique, on autonomic cardiovascular/respiratory physiological functions (systolic pressure, rates of breathing and pulse, and diastolic pressure), tinnitus annoyance (TA), tinnitus loudness (TL), and quality of life measures as tinnitus handicap inventory (THI) did not receive significant attention.

Objective: This study aimed to investigate the efficacy of BHRT on TL, THI, TA, and cardiovascular/respiratory autonomic functions in bilateral CST elderly (aged ≥65 years old).

The Design, Setting, Participants, And Intervention: The current study employs a prospective, single-blind design; it is a randomized-controlled for-tinnitus behavioral intervention.

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Chemotherapy is an important means of cancer treatment. However, overexpression of efflux transporters (including but not limited to P-gp and BCRP) can lead to resistance to cancer chemotherapy. Multiple-target inhibitors of efflux transporter can be overcome the resistance and improve the oral bioavailability of chemotherapy drugs.

Agenesis of vermiform appendix; a case report with literature review.

Introduction: Agenesis of the vermiform appendix (AVA) is a very rare finding. The report aims to present a case of suspected acute appendicitis who lacked vermiform appendix during surgical exploration.

Case Presentation: A 25-year-old pregnant lady was presented with abdominal pain for a period of 2 days.

Estimation and Comparison of the Duration of the Pubertal Peak in Skeletal Class II and Class I Subjects Using the Cervical Vertebrae Maturation Index Method.

Aim: The purpose of this study is to estimate and compare the duration of the pubertal peak in skeletal class II and class I subjects and to detect any difference between boys and girls or between hypo-, normo-, and hyperdivergent subjects for skeletal maturation indicator (CVM) in white Caucasians.

Materials And Methods: 346 subjects were selected from 3,119 examined files. Pretreatment lateral cephalometric records were hand-traced and divided following the anteroposterior skeletal relationship, the gender, the vertical pattern, and the skeletal maturation.

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.

Multidrug resistance (MDR) refers to the cross-resistance of cancer cells to one drug, accompanied by other drugs with different mechanisms and structures, which is one of the main obstacles of clinical chemotherapy. Overexpression of P-glycoprotein (P-gp) was an extensively studied cause of MDR. Therefore, inhibiting P-gp have become an important strategy to reverse MDR.

Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide.

Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a phenylquinoline platform that evolved from Cinchophen lead. This design composes three sections: a phenylquinoline headgroup attached to an aliphatic carboxamides, which is tethered at a phenyl tail group. Optimization of this design led to the identification of 37, comprising a pyrrolidine linker and a trifluoromethyl-phenyl tail.

Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.

Cancer chemotherapy failure is often due to the overexpression of ATP-binding cassette (ABC) transporters (particularly ABCB1), resulting in a variety of structurally and pharmacologically unrelated drugs efflux. The multidrug resistance (MDR) phenomenon could be reversed by ABCB1 inhibitors. Now, JL-A7 as the lead compound based on a triazol-N-ethyl-tetrahydroisoquinoline scaffold, 18 compounds were designed and synthesized.

Geraniol alleviates diabetic cardiac complications: Effect on cardiac ischemia and oxidative stress.

The present study was planned to assess the possible protective effect of geraniol on cardiovascular complications in an animal model with diabetes. Diabetes was induced in rats by a single streptozotocin injection. In the treated group, geraniol (150mgkgday) was administered orally starting from the 15th day after induction of diabetes, and ending after 7 weeks; diabetic control rats were given vehicle for the same period.

Poisonous plants contaminating edible ones and toxic substances in plant foods. Part 3. Pyrrolizidine alkaloids from Heliotropium digynum Forssk. (= H. luteum, Poir.).

Investigation of the alkaloidal constituents of Heliotropium digynum resulted in the isolation of four alkaloids viz. heliotrine, europine, lasiocarpine and 7-angelylheliotrine. Moreover, HPLC and GLC showed the probable presence of heliotridine and some other unidentified minor constituents.

Pharmacological effects of althesin and its steroidal components on the cardiovascular system.

Althesin and its two steroidal components elicited, despite a deficit vasopressor effect by their solvent vehicle Cremophor El, a well-marked hypotensive activity appearing abruptly after i.v. injection in chloralosed cats.