Inducible Nitric Oxide Synthase iNOS-954-G>C and Ex16+14-C>T Gene Polymorphisms and Susceptibility to Vitiligo in the Saudi Population.

Objective: Vitiligo is an acquired pigmentary skin disorder with regional disappearance of melanocytes. Multigenic inheritance has been proposed in the pathogenesis of vitiligo. The present study aimed to investigate the possible association of inducible nitric oxide synthase polymorphisms iNOS-954-G/C (rs1800482 G>C) and iNOS-Ex16+14-C/T (rs2297518 C>T) with vitiligo in the Saudi population, if any.

Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo.

The is associated with susceptibility to autoimmune diseases. The functional polymorphism in at 1857 is a strong risk factor for vitiligo susceptibility in Europeans; however, controversy exits in other populations. Present study was aimed to determine whether the PTPN22 C1857T polymorphism confers susceptibility to vitiligo in Saudi Arabians.

C677T Gene Polymorphism as Risk Factor for Psoriasis in Saudis.

has been linked with the etiopathogenesis of psoriasis with inconsistent results. C677T polymorphism was evaluated in 106 Saudi psoriasis vulgaris patients and 280 matched healthy controls using PCR-RFLP (restriction fragment length plymorphism) technique. The cardiovascular risk factors were also compared in cases and controls.

Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study.

The cause of atopic dermatitis (AD) is multifactorial and a number of genes including cytokines have been involved. We genotyped 315 subjects for polymorphisms in and and genes. Patients had significantly higher frequency of GA genotype of TNF-α (-308 G/A) than healthy controls.

The Protein Tyrosine Phosphatase Nonreceptor 22 () R620W Functional Polymorphism in Psoriasis.

Background: Psoriasis is a complex autoimmune disease caused by the interaction of genetic and environmental factors. gene polymorphism has been reported to affect psoriasis susceptibility; however, no data are available for Middle Eastern populations.

Objective: The aim of this study was to investigate the association of PTPN22 (1858C/T) R620W polymorphism with psoriasis in a Saudi cohort.

Apolipoprotein E gene polymorphism and serum lipid profile in Saudi patients with psoriasis.

Background/aim: Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients.