Effective synthesis and characterization of citric acid cross-linking of modified ferrous metal-organic framework and chitosan nanocomposite sponge for Th(IV) elimination: Adsorption isotherms, kinetic analysis, and optimization by Box-Behnken design.

This research presents a novel nanocomposite of ferrous metal-organic framework (Fe(II)-MOF) that has been encapsulated with chitosan matrix, leading to the development of a new adsorbent referred to as NH-Fe(II)-MOF@CSC composite sponge. This composite sponge has shown effectiveness in removing radioactive thorium (IV) contamination from water sources. The adsorbent underwent characterization using techniques including FTIR, PXRD, BET analysis, and SEM.

Design, Synthesis, Computational Investigations, and Antitumor Evaluation of -Rhodanine Glycosides Derivatives as Potent DNA Intercalation and Topo II Inhibition against Cancer Cells.

Nitrogen and sulfur glycosylation was carried out via the reaction of rhodanine () with α-acetobromoglucose under basic conditions. Deacetylation of the protected nitrogen nucleoside was performed with CHONa in CHOH without cleavage of the rhodanine ring to afford the deprotected nitrogen nucleoside . Further, deacetylation of the protected sulfur nucleoside was performed with CHONa in CHOH with the cleavage of the rhodanine ring to give the hydrolysis product .

Design, synthesis, molecular modelling and antitumor evaluation of -glucosylated rhodanines through topo II inhibition and DNA intercalation.

In the present study, 5-arylidene rhodanine derivatives , -glucosylation rhodanine , -glucosylation rhodanine , -glucoside rhodanine and -glucosylation 5-arylidene rhodanines were synthesised and screened for cytotoxicity against a panel of cancer cells with investigating the effective molecular target and mechanistic cell death. The anomers were separated by flash column chromatography and their configurations were assigned by NMR spectroscopy. The stable structures of the compounds under study were modelled on a molecular level, and DFT calculations were carried out at the B3LYP/6-31 + G (d,p) level to examine their electronic and geometric features.

Anticandidal activity of the extract and compounds isolated from Rottb.

The phytochemical screening of showed that carbohydrates and/or glycosides, flavonoids, tannins, sterols and/or triterpenes, and proteins and/or amino acids are present. The fatty acid profile comprised major; palmitic, oleic, heptadecanoic, linoleic and minor; arachidonic, lignoceric, stearic, and myristic acid. Two compounds; namely, α-amyrin and β-sitosterol were isolated by the fractionation of unsaponifiable matter.