Publications by authors named "Ghaderi A"
Background: To overcome the limitations of IL-15 and to improve the efficacy of IL-15 in immunotherapy, several strategies have been introduced.
Objective: The objective of this study was to generate and evaluate a novel anti-CD8/IL-15 (N72D)/Sushi fusion protein with the potential to target CD8 T cells and enhance functionality of CD8 T cells against tumor cells.
Methods: In this connection, a novel fusokine that contains IL-15(N72D), a Sushi domain, and anti-CD8 single-chain fragment variable (scFv) was designed.
Background/objectives: Nurse-like cells (NLCs) derived from monocytes in the tumor microenvironment support the growth of chronic lymphocytic leukemia (CLL) cells. Here, we investigated the effects of a CX3CR1 (fractalkine receptor) antagonist (KAND567) on autologous monocytes and their pro-survival effects on CLL cells in vitro.
Methods: Plasma concentration of CX3CL1 was determined by ELISA and CX3CR1 expression by flow cytometry.
Background: Oral Squamous Cell Carcinoma (OSCC) is a pressing global health challenge. Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators. Among these, the lncRNA ANRIL (antisense non-coding RNA in the INK4 locus) has a role in cancer progression.
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- GABA receptors are linked to drug addiction, sleep issues, and aging, but their interrelationships are not well researched; this study focuses on how blocking these receptors influences methamphetamine (METH) reward memory in sleep-deprived rats.
- Adult and adolescent male Wistar rats underwent seven days of rapid-eye movement sleep deprivation and then were conditioned with METH before testing their memory retrieval after administering the GABA receptor agonist baclofen.
- Baclofen reduced METH reward memory retrieval in both age groups, with stronger effects seen in adolescents, and the high dose lowered GABA overexpression in adolescent rats, suggesting age and sleep deprivation play significant roles in addiction mechanisms.
Large-scale fermentations (»100 m³) often encounter concentration gradients which may significantly affect microbial activities and production performance. Reliably investigating such scenarios in silico would allow to optimize bioproduction. But related simulations are very rare in particular for large bubble columns.
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- Candida parapsilosis is a major fungus contributing to nail infections, known for forming biofilms that resist standard antifungal treatments.
- This research focused on evaluating the effectiveness of the antifungal drug itraconazole against biofilms of C. parapsilosis, examining its ability to induce reactive oxygen species (ROS) that lead to cell death.
- The findings suggest that targeting ROS can enhance the effectiveness of antifungal therapy, particularly for stubborn cases of nail fungus, highlighting the potential of itraconazole as a key treatment option.
Family therapy for eating disorders (ED) is well-established and represents the treatment choice for ED in children and adolescents according to guidelines, with cognitive behavior therapy (CBT) as a second line treatment. There is limited knowledge about how these treatments work in routine clinical care. The goal of the present meta-analysis is to investigate the effectiveness of family therapy and CBT for various EDs in children and adolescents when carried out in routine clinical care.
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- Thalassemia is a genetic blood disorder that affects many people globally, with around 50,000 to 60,000 infants diagnosed each year.
- The primary treatment involves blood transfusions, which can lead to serious iron overload, managed through iron chelation therapy that may cause skin complications like rashes and photosensitivity.
- The article outlines strategies to treat these skin issues, including patient education, regular skin checks, sun protection, topical treatments, and the need for collaboration between hematologists and dermatologists for better patient care.
The orexinergic system and its receptors are involved in many physiological processes. Their functions in energy homeostasis, arousal, cognition, stress processing, endocrine functions, and pain modulation have been investigated. Many studies have shown that the orexinergic system cooperates with the dopaminergic system in the addiction process.
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- Total joint arthroplasty (TJA) significantly improves life quality for arthritis patients, but the procedure's increased demand has led to financial burdens on healthcare due to complications like periprosthetic joint infections (PJIs).
- A systematic review analyzed 12 studies with 42,592 TJA patients to assess the impact of asymptomatic bacteriuria (ASB) on infection risks, revealing that ASB was linked to a higher incidence of PJIs and superficial wound infections.
- The findings suggest ASB raises infection risks for TJA patients, but the bacteria from ASB do not match those found in PJIs, indicating a need to rethink the direct causative role of ASB microorganisms in post-surgery infections.
Background: All orthopaedic procedures, comprising foot and ankle surgeries, seemed to show a positive trend, recently. Bone grafts are commonly employed to fix bone abnormalities resulting from trauma, disease, or other medical conditions. This study specifically focuses on reviewing the safety and efficacy of various bone substitutes used exclusively in foot and ankle surgeries, comparing them to autologous bone grafts.
View Article and Find Full Text PDFIntroduction: Burn injuries lead to dysregulation of immune molecules, impacting cellular and humoral immune pathways. This study aims to determine the prediction of immune molecule activity during burn wound healing among elderly patients.
Methods: The current study utilized the Gene Expression Omnibus (GEO) database to extract the proper gene set.
Lung cancer is one of the most prevalent malignancies worldwide, contributing to over a million cancer-related deaths annually. Despite extensive research investigating the genetic factors associated with lung cancer susceptibility and prognosis, few studies have explored genetic predispositions regarding the immune system. This review discusses the most recent genomic findings related to the susceptibility to or protection against lung cancer, patient survival, and therapeutic responses.
View Article and Find Full Text PDFIn our study, blood concentrations of lead (Pb), arsenic (As), and cadmium (Cd) and urine concentrations of thallium (Tl) were measured together with related symptoms of heavy metal poisoning in cigarette smoking volunteers diagnosed with schizophrenia, in cigarette smokers not diagnosed with schizophrenia, and in the control group of non-smokers and not diagnosed with schizophrenia volunteers. Our study was performed on 171 volunteers divided into the following subgroups: patients diagnosed with schizophrenia with at least 1 year of continuous cigarette smoking experience (56 participants), cigarette smokers not diagnosed with schizophrenia with at least one year of continuous smoking experience (58), and control group (not diagnosed with schizophrenia and non-smoking volunteers) (57). Smoking durations of cigarette smokers diagnosed with schizophrenia and cigarette smokers not diagnosed with schizophrenia are not similar (p = 0.
View Article and Find Full Text PDFTinea incognita (TI) can mimic other dermatoses, presenting a diagnostic challenge for dermatologists. In some uncertain cases, it is crucial to accurately identify the causative agent using internal transcribed spacer (ITS) sequencing. The global issue of drug-resistant dermatophytosis is increasing, with Trichophyton (T.
View Article and Find Full Text PDFBackground: To predict outcomes and identify potential therapeutic targets for cancers, it is critical to find novel specific biomarkers. The objective of this study was to search for and explore novel bladder cancer-associated protein biomarkers.
Methods: A library of monoclonal antibodies (mAbs) against the JAM-ICR cell line was first generated, and clones with high affinity were selected.
Objective: To assess the possible association of two single-nucleotide polymorphisms (SNPs), PD-1.3 (+7146G/A) and PD-1.5 (+7785C/T), with endometrial cancer (EC) susceptibility.
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- - Recalcitrant dermatophytosis, mainly caused by Trichophyton indotineae, is becoming a significant issue globally, with a longer disease duration noted in patients infected by this strain.
- - The study identified various fungal isolates from infected skin samples, highlighting that 88.33% of T. mentagrophytes complex isolates were T. indotineae, and findings indicated that steroid use contributes significantly to the emergence of these infections.
- - For efficient diagnosis and treatment to counteract recalcitrant cases, direct skin sample PCR is recommended, due to its effectiveness in yielding reliable results similar to traditional methods.
Background: Breast cancer is the most common cancer in females. The immune system has a crucial role in the fight against cancer. B and T cells, the two main components of the adaptive immunity, are critical players that specifically target tumor cells.
View Article and Find Full Text PDFIL-21 is a cytokine with versatile antitumor and pro-tumorigenic activities. It is mainly produced by CD4+ T cells and B cells are one of its pivotal targets. In this study, we assessed and compared the expression of IL-21 by CD4+ T cells and the IL-21 receptor (IL-21R) on B cells in the peripheral blood of women with breast cancer and healthy individuals.
View Article and Find Full Text PDFBackground: Eating disorders (EDs) present a growing concern due to their widespread occurrence and chronic course, the low access to evidence-based treatment, and the significant burden they place on the patients and society. This picture justifies intensive focus on the prevention of EDs. The current study provides the first bibliometric analysis of research on the prevention of EDs, focusing on trends and contributions, to prompt further prevention research.
View Article and Find Full Text PDFThere are over 40 million displaced children and youth worldwide and there is a need promote their mental wellbeing. This study aimed to synthesize evidence regarding promotion interventions to increase wellbeing, resilience, and quality of life (primary outcomes), and prevention interventions to reduce internalizing and externalizing symptoms (secondary outcomes) in this population. The review protocol was registered with PROSPERO (CRD42022329978).
View Article and Find Full Text PDFIn line with global goals to solve marine biofouling challenges, this study proposes an approach to developing a green synthesis inspired by natural resources for fouling-resistant behavior. A hybrid antifouling/foul release (HAF) coating based on poly(dimethylsiloxane) containing a green synthesized nanocomposite was developed as an environmentally friendly strategy. The nanocomposites based on graphene oxide (GO) and using marine sources, leaves, and stems of mangroves (), brown algae (), and zinc oxide were compared.
View Article and Find Full Text PDFAlpha oscillations have been implicated in time perception, yet a consensus on their precise role remains elusive. This study directly investigates this relationship by examining the impact of alpha oscillations on time perception. Resting-state EEG recordings were used to extract peak alpha frequency (PAF) and peak alpha power (PAP) characteristics.
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- In a study involving 105 EC patients and 105 healthy controls, researchers found significantly higher IL-37 serum levels in EC patients, which were linked to more aggressive cancer characteristics.
- Despite the elevated IL-37 levels, there was no significant difference in the IL-37 gene genotype between the two groups, suggesting that IL-37 may be a potential therapeutic target for EC but requires further research to confirm its role.