Publications by authors named "Ghada Boulahia"
Article Synopsis
- The COVID-19 pandemic significantly impacted patients with end-stage kidney disease (ESKD), highlighting the importance of vaccination, particularly with mRNA vaccines, which improve outcomes like hospitalization and mortality.
- A study involving 117 fully vaccinated ESKD patients identified three distinct groups based on their immunological responses to the vaccine.
- These groups included women with long dialysis histories and men with diabetes showing low antibody levels, while a third group of non-diabetic middle-aged men had a strong positive vaccine response, allowing for personalized vaccination strategies.
Article Synopsis
- Iron overload is a growing concern in patients undergoing haemodialysis due to excessive parenteral iron use, with a previous paradox where bone marrow iron levels were low despite high liver iron content.
- Recent studies, including an autopsy study and a retrospective analysis of 152 living dialysis patients, show that this paradox no longer exists, as patients with liver iron overload also have increased iron levels in the bone marrow.
- Significant differences in vertebral T2 measurements were found, indicating that those with mild to severe liver iron overload had lower T2 values (higher vertebral iron content) compared to patients with normal liver iron levels.
Article Synopsis
- Anemia is a common issue in patients with end-stage kidney disease (ESKD), and current treatments include erythropoiesis-stimulating agents and intravenous (IV) iron.
- A study compared the liver accumulation of iron from IV iron sucrose versus two newer options, ferric carboxymaltose and iron isomaltoside, in dialysis patients.
- Results showed that IV iron sucrose significantly increased liver iron concentration, while the newer agents had much less impact, indicating they may be safer for treating anemia in ESKD.
Calciphylaxis is a small vessel vasculopathy, characterized by medial wall calcification that develops in a few patients with chronic renal failure. The prognosis of skin calciphylaxis has improved considerably since the introduction of sodium thiosulfate (STS), but it remains unclear whether this therapy is effective against organ lesions related to calciphylaxis. Pulmonary calciphylaxis is a usually fatal medical condition that may occur in association with skin involvement in patients with end-stage renal disease.
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