Cytotoxic pregnane glycosides from (Forssk.).

(Forssk.) is a medicinal succulent plant belonging to the family Apocynaceae. The phytochemical examination of methanolic extract resulted in isolation of three unique new pregnane glycosides, quadrangulosides G-I (), their structures were elucidated utilising 1D, 2D NMR and ESI MS spectral studies.

Quadrangulosides A-F: new pregnane glycosides from .

The phytochemical investigation of aerial parts yielded six new pregnane glycosides, quadrangulosides A-F (1-6), in addition to nine known pregnane glycosides and three known flavone glycosides. Structures of isolated phyto-constituents were elucidated spectroscopic 1D-, 2D-NMR and spectrometric ESI-MS spectra.

The influence of interferon-β supplemented human dendritic cells on BCG immunogenicity.

Introduction: Tuberculosis (TB) remains a huge worldwide burden, despite extensive vaccination coverage with the Bacillus Calmette-Guérin (BCG), the only vaccine available against this disease, indicating that BCG-driven immunity is inadequate to protect the human population against TB. This underscore the critical necessitate to develop an improved TB vaccine, based on a better understanding of host-pathogen interactions and immune responses during mycobacterial infection.

Aim Of The Work: To examine whether the exogenous addition of IFN-β could improve dendritic cell (DC) response to Mycobacterium bovis (M.