Bone loss with multiple sclerosis: effect of glucocorticoid use and functional status.

Background: Emerging data suggest a significantly increased prevalence of low bone mineral density (BMD) in men and women with multiple sclerosis (MS) compared to age matched controls. This study was performed to evaluate bone mineral mass in patients with MS in comparison to healthy age-and sex matched controls and to determine association of glucocorticoid use or ambulation ability with changing in bone mass in these individuals.

Methods: Eighty two patients with MS and 328 age-sex matched healthy controls participated in the study.