Publications by authors named "Geza Benke"

Article Synopsis
  • Further research on identified regions could enhance our understanding of genetic risks for glioma.
  • The study indicates that sex might influence genetic susceptibility to glioma.
  • It emphasizes the need for future glioma studies to consider sex-specific factors in their analyses.*
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Radiofrequency electromagnetic fields (RF-EMF, 100 kHz to 300 GHz) are classified by IARC as possibly carcinogenic to humans (Group 2B). This study evaluates the potential association between occupational RF-EMF exposure and brain tumor risk, utilizing for the first time, a RF-EMF job-exposure matrix (RF-JEM) developed in the multi-country INTEROCC case-control study. Cumulative and time-weighted average (TWA) occupational RF-EMF exposures were estimated for study participants based on lifetime job histories linked to the RF-JEM using three different methods: (1) by considering RF-EMF intensity among all exposed jobs, (2) by considering RF-EMF intensity among jobs with an exposure prevalence ≥ the median exposure prevalence of all exposed jobs, and (3) by considering RF-EMF intensity of jobs of participants who reported RF-EMF source use.

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Background: We aimed to assess evidence of long-term effects of exposure to radiofrequency (RF) electromagnetic fields (EMF) on indicators of cognition, including domains of learning and memory, executive function, complex attention, language, perceptual motor ability and social cognition, and of an exposure-response relationship between RF-EMF and cognition.

Methods: We searched PubMed, Embase, PsycInfo and the EMF-Portal on September 30, 2022 without limiting by date or language of publication. We included cohort or case-control studies that evaluated the effects of RF exposure on cognitive function in one or more of the cognitive domains.

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Article Synopsis
  • The study investigates changes in personal RF-EMF exposure in Australia from 2015-2016 to 2022, focusing on how advancements in telecommunication technology may affect exposure levels over time.
  • Data was collected from 18 different micro-environments in Melbourne, and simultaneous quantile regression was used to analyze the differences in median and overall exposure trends among various sources.
  • Results indicate that total RF-EMF exposure levels remained relatively stable, but there was a noticeable increase in exposure from mobile downlink, with five out of seven micro-environments showing rising exposure trends at the follow-up.
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Purpose: Tobacco smoking is the major risk factor for COPD, and it is common for other risk factors in never-smokers to be overlooked. We examined the prevalence of COPD among never-smokers in Australia and identified associated risk factors.

Methods: We used data from the Australia Burden of Obstructive Lung Disease (BOLD) study, a cross-section of people aged ≥40 years from six sites.

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Background: Certain occupational characteristics have been linked with poor health and reduced longevity. However, the association between occupational characteristics and survival free of disability in a post-retirement age group has not been investigated.

Methods: We investigated outcomes in 12,215 healthy older Australian adults in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE Longitudinal Study of Older Persons (ALSOP) sub-study.

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Background: Epidemiologic evidence suggests an inverse association between sun exposure and follicular lymphoma risk.

Methods: We conducted an Australian population-based family case-control study based on 666 cases and 459 controls (288 related, 171 unrelated). Participants completed a lifetime residence and work calendar and recalled outdoor hours on weekdays, weekends, and holidays in the warmer and cooler months at ages 10, 20, 30, and 40 years, and clothing types worn in the warmer months.

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Objectives: There is a scarcity of evidence on occupational exposures that may increase eczema in adults. We aimed to investigate potential associations between occupational exposures and eczema in middle-aged adults.

Methods: A lifetime work history calendar was collected from the Tasmanian Longitudinal Health Study participants when they were at age 53.

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Objectives: We aimed to examine the relationship between occupational exposure to extremely low-frequency magnetic fields (ELF-MFs) and follicular lymphoma (FL) risk.

Methods: We conducted a family case-control study between 2011 and 2016 in Australia and included 681 cases. Controls were either a family member of cases (related (n=294), unrelated (n=179)) or were unrelated recruited for a similarly designed Australian multiple myeloma study (n=711).

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Objectives: Malignant mesothelioma is an uncommon cancer associated with asbestos exposure, predominantly occupational. Asbestos has been banned in Australia since 2003 but mesothelioma has a long latency and incident cases continue to present. The Australian Mesothelioma Registry was incepted to collect systematic data about incidence and mortality alongside asbestos exposure.

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Objectives: To investigate mortality and the rates of incident cancer among a cohort of aluminium industry workers.

Methods: Among 4507 male employees who worked in either of two Australian prebake smelters for at least 3 months, data linkage was undertaken with the Australian National Death Index and Australian Cancer Database. Standardised Mortality Ratios (SMRs) and Standardised Incidence Rates (SIRs) were estimated for the whole cohort and for: production; maintenance and office workers.

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Background: The association between dietary intake of foods of animal origin and follicular lymphoma (FL) risk and survival is uncertain. In this study, we examined the relationship between dietary intake of dairy foods and fats, meat, fish and seafoods, and the likelihood of FL and survival.

Methods: We conducted a population-based family case-control study in Australia between 2011 and 2016 and included 710 cases, 303 siblings and 186 spouse/partner controls.

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Article Synopsis
  • Glioma is a major form of malignant brain cancer, with glioblastoma being particularly deadly, so researchers conducted a genetic study in Australia to explore risk factors by subtype and sex.
  • They analyzed genetic data for over 560 glioma cases and 2,237 controls, focusing on specific genetic variations (SNPs) linked to glioma risk, using logistic regression for their analysis.
  • The study confirmed earlier findings about certain genetic regions related to glioma risk, particularly emphasizing a stronger risk association in females for the 8q24.21 region, suggesting that understanding sex differences could improve prevention and treatment strategies.
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Objectives: Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies.

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Objectives: Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin's lymphoma (NHL) in a large, pooled study.

Methods: We pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate).

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Background: The influence of early-life growth pattern and body size on follicular lymphoma (FL) risk and survival is unclear. In this study, we aimed to investigate the association between gestational age, growth during childhood, body size, changes in body shape over time, and FL risk and survival.

Methods: We conducted a population-based family case-control study and included 706 cases and 490 controls.

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Article Synopsis
  • Modern human populations are constantly exposed to RF-EMFs mainly from telecommunications and broadcasting technologies, raising public concerns about potential health impacts.
  • To address these concerns, objective assessment of RF-EMF exposure is vital for investigating possible health effects among people.
  • The review highlights advancements in tools for measuring RF-EMF exposure, including mobile phone-based and standalone devices, improving the accuracy of assessments in epidemiological studies.
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The association between smoking and alcohol consumption and follicular lymphoma (FL) incidence and clinical outcome is uncertain. We conducted a population-based family case-control study (709 cases: 490 controls) in Australia. We assessed lifetime history of smoking and recent alcohol consumption and followed-up cases (median = 83 months).

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Little was known about the relationship between carrying mobile phone handsets by men and their risk perception of radiofrequency-electromagnetic field (RF-EMF) exposure due to carrying handsets close to the body. This study aimed to determine where men usually carried their handsets and to assess the relationship to risk perception of RF-EMF. Participants completed a self-administered questionnaire about mobile phone use, handset carrying locations, and levels of risk perception to RF-EMF.

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Purpose: High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality.

Methods: We examined associations between lifetime physical activity and physical activity at different ages (15-18 years, 19-29 years, 30-39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case-control study (495 cases; 371 controls).

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At a major hazard facility, cases of occupational noise-induced hearing loss have occurred despite the use of hearing protection devices. Preliminary measurements of personal attenuation ratings (PAR) suggested that earplugs may not achieve the attenuation implied by their Australian SLC80 Class designation in field-use conditions. We examined the relationship between PAR and the SLC80 classification for earplugs, as a good understanding of the attenuation provided by earplugs under normal field-use conditions, rather than in laboratory settings, is vital to their effective use as a control measure for noise exposure.

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Article Synopsis
  • - This text discusses the long-term effects of exposure to radiofrequency (RF) electromagnetic fields (EMF) from sources like mobile phones on cognitive performance and highlights the need for observational studies to assess these effects over time.
  • - The objectives include evaluating how different levels of RF EMF exposure impact various cognitive abilities, like memory and attention, while excluding cognitive effects related to neurodegenerative diseases.
  • - The study will focus on observational research that compares different exposure levels, emphasizing the importance of valid cognitive function measures across long-term follow-ups of at least six months.
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Background: Classifying individuals at high chronic obstructive pulmonary disease (COPD)-risk creates opportunities for early COPD detection and active intervention.

Objective: To develop and validate a statistical model to predict 10-year probabilities of COPD defined by post-bronchodilator airflow obstruction (post-BD-AO; forced expiratory volume in 1 s/forced vital capacity<5th percentile).

Setting: General Caucasian populations from Australia and Europe, 10 and 27 centres, respectively.

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Article Synopsis
  • A study examined the link between occupational insecticide use and non-Hodgkin lymphoma (NHL) risk, analyzing data from 9 case-control studies across various regions with nearly 8,000 cases and 8,600 controls.
  • Overall, occupational insecticide use was not linked to NHL, but specific types, like organophosphates and carbaryl, showed increased risk for all NHL and certain subtypes.
  • The findings highlight the need for public health agencies to consider the risks associated with continued use of organophosphate and carbamate insecticides based on the evidence gathered.
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