Magnetic resonance imaging-controlled laser-induced interstitial thermotherapy.

Rationale And Objectives: Laser-induced interstitial thermotherapy (LITT) may become an attractive modality for minimally invasive tumor therapy. Magnetic resonance imaging (MRI) could be used to assist this procedure.

Methods: A T1-weighted turbo fast low-angle shot (FLASH) sequence for on-line monitoring of the laser-influenced region (liver, muscle) was investigated.

Electron microscopic and 31-P NMR studies of ischemic injured rat livers during preservation and reflow.

Ischemic injury induced during preservation and reperfusion contributes to post-operative failure in liver transplantation. Hepatic injury and recovery from preservation was studied in an isolated rat liver model reperfused with oxygenated erythrocytes. In order to correlate morphological and functional findings, 31-P nuclear magnetic resonance spectroscopy and electron microscopy were used to investigate metabolic and ultrastructural changes during 6 hours of reperfusion.

Liver tumors: follow-up with P-31 MR spectroscopy after local chemotherapy and chemoembolization.

The authors examined and quantified the changes observed in the phosphorus-31 magnetic resonance (MR) spectra of liver tumors after chemotherapy and chemoembolization to investigate the suitability of P-31 MR spectroscopy for follow-up. A 1.5-T unit was used before and at specific times during therapy to obtain spectra of liver tumors in 10 patients with liver metastases from colorectal carcinoma and two patients with hepatocellular carcinoma.

Effect of pentoxiphylline on the recovery of the preserved rat liver: 31P NMR and ultrastructural studies.

Hepatic failure often occurs following transplantation. This is primarily due to cold ischemia during preservation, warm ischemia during implantation, and finally reperfusion damage after transplantation and reflow. The possibility that this ischemia and reperfusion-induced damage can be reduced by preischemic application of a xanthine derivative (pentoxiphylline) was examined using 31P NMR spectroscopy and electron microscopy (EM) studies of bioenergetic and ultrastructural changes in oxygenated erythrocyte-perfused rat livers.

31P nuclear magnetic resonance spectroscopy, histology and cytokinetics of a xenografted hypopharynx carcinoma following treatment with cisplatin: comparison in three sublines with increasing resistance.

The changes in the phosphorus metabolism of a xenografted hypopharynx carcinoma (Hyp 1), sensitive to cisplatin (CDDP), were compared to those occurring in two sublines of the tumour, characterised by moderate or high resistance to CDDP (Hyp 1/H and Hyp 1/R) following, i.p. administration of 4, 8 or 12 mg CDDP/kg-1.

[The effect of nutritional status on the 31P MR spectrum of the normal liver].

Previous investigations in animal and human liver spectroscopy revealed a strong effect of metabolic activity on the 31P-spectra of the liver. This study examined the influence of a standardised meal on the liver spectra of healthy volunteers. The measurements were performed at 1.

[Magnet resonance spectroscopy of tumor-bearing rat livers: magnetite particles as an aid in volume selection].

Magnetite, an RES-specific contrast medium, has been used in animal experiments and in a few patients for MRI of the liver. We examined the use of magnetite particles for 31P-MR spectroscopy using a phantom, and perfused tumour-bearing rat livers and liver tumours in living rats. As expected, there is homogeneous uptake of the magnetite in normal liver leading to extinction of the signal when one uses suitable spectroscopic parameters.

[Effect of static magnetic fields on the acoustic action potential of the cochlea in guinea pigs].

Several experiments carried out during the past years indicate that strong magnetic fields induce disturbed blood circulation in capillaries and arterioles. When exposed to a magnetic field, disturbed blood circulation was found in the capillaries in frog webs as well as changes in skin temperature in several kinds of species. In our experiments we assessed the influence of a 8.