Today, diabetes mellitus is an urgent and topical medical and social problem of modern medicine. In the era of industrialization, this endocrine disorder's incidence increases exponentially, affecting more broadly, especially the young cohorts of the population, thereby exerting a substantial burden on the health system. Comprehension and full-fledged study of the pathophysiological mechanisms and remodeling dynamics in the diabetic continuum will ensure further advances in modern diabetology to set it to a potentially new level.
View Article and Find Full Text PDFObjective: The wide-ranging manipulations to the cardiovascular system that frequently occur during cardiac surgery can expose the brain to variations in its blood supply that could prove deleterious. As a first step to developing a resource suitable for monitoring such changes, we detected the hemodynamic events induced in the brain of a primate model, using high-density near-infrared spectroscopy combined with tomographic reconstruction methods and validated the findings using established radiologic and histologic techniques.
Methods: Continuous monitoring of the relative changes in the components of the cerebral hemoglobin signal was performed using high-density near-infrared spectroscopy (270 source-detector channel array) in anesthetized bonnet macaques with the brain exposed to induced ischemia and other acute events.
We study nonlinear phenomena of bistability and chaos at a level of few quanta. For this purpose, we consider a single-mode dissipative oscillator with strong Kerr nonlinearity with respect to the dissipation rate driven by a monochromatic force as well as by a train of Gaussian pulses. The quantum effects and decoherence in the oscillatory mode are investigated in the framework of the purity of states and the Wigner functions calculated from the master equation.
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