Stretching multistate flexible chains and loops.

Polymer loop structure commonly appears in biological phenomena, such as DNA looping and DNA denaturation. When a chain forms a loop, its elastic behavior differs from that of an open chain due to the loss of entropy. In the case of reversible loop formation, interesting behavior emerges related to the multistate nature of the conformations.

Tensile elasticity of a freely jointed chain with reversible hinges.

Many biopolymers exhibit reversible conformational transitions within the chain, which affect their bending stiffness and their response to a stretching force. For example, double stranded DNA may have denatured "bubbles" of unzipped single strands which open and close randomly. In other polymers, the transitions may be due to the reversible attachment and detachment of ligands on ligand-receptor complexes along the backbone.