Multi-proteomic analyses of 5xFAD mice reveal new molecular signatures of early-stage Alzheimer's disease.

An early diagnosis of Alzheimer's disease is crucial as treatment efficacy is limited to the early stages. However, the current diagnostic methods are limited to mid or later stages of disease development owing to the limitations of clinical examinations and amyloid plaque imaging. Therefore, this study aimed to identify molecular signatures including blood plasma extracellular vesicle biomarker proteins associated with Alzheimer's disease to aid early-stage diagnosis.

Influence of the subfactors of self-compassion on burnout among hospital nurses: A cross-sectional study in South Korea.

Aim: This study aimed to identify the effects of the subfactors of self-compassion on hospital nurse burnout and provide basic knowledge for an intervention programme to prevent nurse burnout.

Background: Burnout in nurses has been reported to influence their own and patients' mental health and safety. Enhancing self-compassion can help to prevent burnout.