Development of multi-model ensemble approach for enhanced assessment of impacts of climate change on climate extremes.

The severity and frequency of climate extremes will change in the future owing to global warming. This can severely impact the natural environment. Therefore, it is common practice to project climate extremes with a global climate model (GCM) in order to quantify and manage the associated risks.

Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial.

Background: The purpose of this study was to determine among maintenance hemodialysis patients with echocardiographic left ventricular hypertrophy and hypertension whether in comparison with a β-blocker-based antihypertensive therapy, an angiotensin converting enzyme-inhibitor-based antihypertensive therapy causes a greater regression of left ventricular hypertrophy.

Methods: Subjects were randomly assigned to either open-label lisinopril (n = 100) or atenolol (n = 100) each administered three times per week after dialysis. Monthly monitored home blood pressure (BP) was controlled to <140/90 mmHg with medications, dry weight adjustment and sodium restriction.

Home blood pressure measurements for managing hypertension in hemodialysis patients.

Home blood pressure (BP) monitoring serves as a practical method to detect changes in BP instead of ambulatory BP monitoring in hemodialysis patients. To evaluate the relationship of reduction in home BP compared to interdialytic ambulatory BP measurements we analyzed the data from the dry-weight reduction in hypertensive hemodialysis patients (DRIP) trial in which 100 patients had their dry weight probed based on clinical sign and symptoms and 50 patients served as controls. We measured home BP 3 times a day for 1 week using a validated oscillometric monitor on 3 occasions at 4-week intervals after randomization.

Assessment of iothalamate plasma clearance: duration of study affects quality of GFR.

Background And Objectives: Measurement of GFR is important for the management of chronic kidney disease (CKD). Although bolus administration of radiocontrast agents is commonly used to measure GFR, the optimal duration of sampling to assess their plasma clearance is unknown. The purpose of this study was to evaluate whether the duration of plasma sampling influences precision and estimation of GFR.

Diagnosing hypertension by intradialytic blood pressure recordings.

Background And Objectives: The diagnosis of hypertension among hemodialysis patients by predialysis or postdialysis blood pressure (BP) recordings is imprecise and biased and has poor test-retest reliability. The use of intradialytic BP measurements to diagnose hypertension is unknown.

Design, Setting, Participants, & Measurements: A diagnostic-test study was done with interdialytic ambulatory BP as reference standard.